Many of us KNOW that God has placed within creation an extraordinary pharmacy of healing substances. Brilliant forward-thinking doctors like Peter McCullough are increasingly confirming that natural compounds possess remarkable biochemical sophistication. Piperine from black pepper, curcumin from turmeric, quercetin from plants, and countless other phytochemicals exhibit complex molecular behaviors that can influence inflammation, detoxification pathways, cellular signaling, and even processes relevant to cancer biology.
Unlike many synthetic pharmaceuticals, which often target a single pathway, natural compounds tend to act in a multi-modal fashion. They may modulate oxidative stress, enhance immune surveillance, support healthy apoptosis, or improve nutrient absorption—all while generally producing fewer side effects. Piperine, for example, is known to increase the bioavailability of several beneficial molecules, suggesting that nature not only provides therapeutic compounds but often packages them with “activation partners” that help the body use them more effectively.
As research advances, scientists are discovering that these substances can be further optimized through nanoformulations to further enhance bioavailability. I would caution against injecting these formulations and stick to ingesting them to allow the epithelial barrier to process them naturally.
Artificial intelligence is now emerging as a powerful ally in this rediscovery of nature’s pharmacology. AI can sift through enormous datasets—genomic libraries, biochemical pathways, clinical observations—and identify patterns no human could see alone. It can predict which natural compounds might synergize, which molecular structures could be improved, and how to design safe, effective formulations in silico before they ever reach the laboratory. In this way, AI may accelerate the development of gentle, nature-aligned therapies that honor the complexity of both the human body and the natural world.
Rather than viewing natural medicine and modern science as opposites, this new era suggests they are partners. The intelligence woven into natural compounds and the analytical power of AI together hold enormous potential for advancing cancer prevention research, supportive care, and broader human health—offering hope for therapies that are both effective and harmonious with the body’s design.
Thank-you for your wonderful contribution to Dr. McCullough's article. One word of caution is that unknown to most, piperine (from black pepper seed extract) can cause gastritis & colitis in some people, which can be alarming, when blood suddenly appears in their stool. Most people will not make the connection.
Using Black Pepper on one's food can be an irritant to the lining of the stomach. The miniscule amount of piperine (black pepper seed extract) in a capsule along with something like turmeric would not be harmful to most people, but there are exceptions. .
Best source of natural preventatives and treatments is Enoch AI produced by Mike Adams, owner of Natural News and Brighteon. And Enoch is FREE and accessible through Brighteon.AI or by doing a search at naturalnews.com
Great info Peter! I was very dismayed when some MD's were recently trying to claim the "pepper" in Cur-cumin supplements hurt us, saying it should be removed! The Natural Health News.com said that would make Cur-cumin supplements 2500 times less effective; I think NHN was correct, the MD's were wrong, and your post shows even more.
Nicholas or Dr. McCullough, please do a comprehensive write up, pulling together all articles, disputing the CDC claim that the best way to avoid the flu this season is to get the flu shot. I know you've done write ups about certain studies on the flu shot, but it would be nice to see all of the information/studies together that show they are not effective or unsafe or cause negative efficacy. CDC recommends flu shot for everyone 6 months and older. See their website linked below.
Wait until those who have been slow to embrace natural substances over pharmaceuticals learn about turmeric paste, and it’s ant-neoplastic qualities. And for decades it’s been known that adding a little freshly cracked black pepper to the paste, it boosts the anti-neoplastic properties massively.
Nice to have this data to back up what’s been known by observation. But it does prove that what’s been shared for generations has indeed been fact. Pharma can’t patent it, so it hasn’t been researched, it just works. And turmeric paste is easy, (and cheap(, to make at home. (Just be careful, because turmeric will stain what it touches.). I’m sure, however, that someone will bottle it and place a hefty price tag on it anyway.
I have read over 5,000 covid related articles, and likely more. It is rare for me to read such a concise report with everything needful--the what, the how, the why; and relevant to "dummy me" ever aspect about piperine dosages that I would want to know. I can tell one off-topic story about piperine. As the youngest kid on my block, a l-o-n-g time ago, when I brought home a new variety of "NO! WORDS" (like "Sh-- No" and "f--- you" (I was about 5 years old) that I learned on the street from the big boys playing street broom stick baseball in Dodger Land. When I repeated what I learned from them to my parents, they washed my mouth out with soap. I didn't like that, but it didn't work. Then they tried crushed black pepper. I hated that, and it worked for awhile, but some words lingered, until my dad used fresh Tobasco sauce on my tongue. It cured my "bad words"! I wonder if tobasco has piperine in it, or an equivalent, or maybe an improvement? Both are hot in young kids mouths, but black pepper is no longer hot for me. Do I need to step up?
Dr. McCullough, can you get with the SubStack leadership and request an option for me to be able to block auto scroll to a channel that I don't subscribe to? It's super annoying. I get so much content off topic and of no interest.
Many of us KNOW that God has placed within creation an extraordinary pharmacy of healing substances. Brilliant forward-thinking doctors like Peter McCullough are increasingly confirming that natural compounds possess remarkable biochemical sophistication. Piperine from black pepper, curcumin from turmeric, quercetin from plants, and countless other phytochemicals exhibit complex molecular behaviors that can influence inflammation, detoxification pathways, cellular signaling, and even processes relevant to cancer biology.
Unlike many synthetic pharmaceuticals, which often target a single pathway, natural compounds tend to act in a multi-modal fashion. They may modulate oxidative stress, enhance immune surveillance, support healthy apoptosis, or improve nutrient absorption—all while generally producing fewer side effects. Piperine, for example, is known to increase the bioavailability of several beneficial molecules, suggesting that nature not only provides therapeutic compounds but often packages them with “activation partners” that help the body use them more effectively.
As research advances, scientists are discovering that these substances can be further optimized through nanoformulations to further enhance bioavailability. I would caution against injecting these formulations and stick to ingesting them to allow the epithelial barrier to process them naturally.
Artificial intelligence is now emerging as a powerful ally in this rediscovery of nature’s pharmacology. AI can sift through enormous datasets—genomic libraries, biochemical pathways, clinical observations—and identify patterns no human could see alone. It can predict which natural compounds might synergize, which molecular structures could be improved, and how to design safe, effective formulations in silico before they ever reach the laboratory. In this way, AI may accelerate the development of gentle, nature-aligned therapies that honor the complexity of both the human body and the natural world.
Rather than viewing natural medicine and modern science as opposites, this new era suggests they are partners. The intelligence woven into natural compounds and the analytical power of AI together hold enormous potential for advancing cancer prevention research, supportive care, and broader human health—offering hope for therapies that are both effective and harmonious with the body’s design.
Thank-you for your wonderful contribution to Dr. McCullough's article. One word of caution is that unknown to most, piperine (from black pepper seed extract) can cause gastritis & colitis in some people, which can be alarming, when blood suddenly appears in their stool. Most people will not make the connection.
Using Black Pepper on one's food can be an irritant to the lining of the stomach. The miniscule amount of piperine (black pepper seed extract) in a capsule along with something like turmeric would not be harmful to most people, but there are exceptions. .
I was one of those exceptions. Hence, my word of caution.
Every person is biochemically unique...What is good for one may not be good for another, even in the same family.
See Enoch AI by Mike Adams at Brighteon.
Best source of natural preventatives and treatments is Enoch AI produced by Mike Adams, owner of Natural News and Brighteon. And Enoch is FREE and accessible through Brighteon.AI or by doing a search at naturalnews.com
Great info Peter! I was very dismayed when some MD's were recently trying to claim the "pepper" in Cur-cumin supplements hurt us, saying it should be removed! The Natural Health News.com said that would make Cur-cumin supplements 2500 times less effective; I think NHN was correct, the MD's were wrong, and your post shows even more.
Nicholas or Dr. McCullough, please do a comprehensive write up, pulling together all articles, disputing the CDC claim that the best way to avoid the flu this season is to get the flu shot. I know you've done write ups about certain studies on the flu shot, but it would be nice to see all of the information/studies together that show they are not effective or unsafe or cause negative efficacy. CDC recommends flu shot for everyone 6 months and older. See their website linked below.
https://www.cdc.gov/flu/season/2025-2026.html
Here's the correct link for the first of the three citations shown aat the end of the article: https://pubmed.ncbi.nlm.nih.gov/40273688/
Wait until those who have been slow to embrace natural substances over pharmaceuticals learn about turmeric paste, and it’s ant-neoplastic qualities. And for decades it’s been known that adding a little freshly cracked black pepper to the paste, it boosts the anti-neoplastic properties massively.
Nice to have this data to back up what’s been known by observation. But it does prove that what’s been shared for generations has indeed been fact. Pharma can’t patent it, so it hasn’t been researched, it just works. And turmeric paste is easy, (and cheap(, to make at home. (Just be careful, because turmeric will stain what it touches.). I’m sure, however, that someone will bottle it and place a hefty price tag on it anyway.
I have read over 5,000 covid related articles, and likely more. It is rare for me to read such a concise report with everything needful--the what, the how, the why; and relevant to "dummy me" ever aspect about piperine dosages that I would want to know. I can tell one off-topic story about piperine. As the youngest kid on my block, a l-o-n-g time ago, when I brought home a new variety of "NO! WORDS" (like "Sh-- No" and "f--- you" (I was about 5 years old) that I learned on the street from the big boys playing street broom stick baseball in Dodger Land. When I repeated what I learned from them to my parents, they washed my mouth out with soap. I didn't like that, but it didn't work. Then they tried crushed black pepper. I hated that, and it worked for awhile, but some words lingered, until my dad used fresh Tobasco sauce on my tongue. It cured my "bad words"! I wonder if tobasco has piperine in it, or an equivalent, or maybe an improvement? Both are hot in young kids mouths, but black pepper is no longer hot for me. Do I need to step up?
Dr. McCullough, can you get with the SubStack leadership and request an option for me to be able to block auto scroll to a channel that I don't subscribe to? It's super annoying. I get so much content off topic and of no interest.