BREAKING--Endogenous Re-adenylation by TENT5A Prolongs Life of mRNA Vaccines in Human Cells

Discovery Explains why Pfizer and Moderna Persist in Certain Cell Lines

By Peter A. McCullough, MD, MPH

Injection of Pfizer and Moderna synthetic mRNA coding for the SARS-CoV-2 Spike protein without proper preclinical scientific studies has led to many clinical questions. Among them is why does mRNA seem to hang around the body for such a long period of time?

Krawczyk, P.S., Mazur, M., Orzeł, W. et al. Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines. Nature (2025). https://doi.org/10.1038/s41586-025-08842-1

Krawczyk et al discovered that both Pfizer and Moderna mRNA strands are scheduled for endogenous breakdown by natural enzymes however some cell lines revive the foreign mRNA by a process of TENT5A re-adenylation. Nowhere in the Pfizer or Moderna dossiers is this process described.