Bromelain, Trypsin, Rutin Supplement Reduces Inflammation--Placebo-Controlled RCT
42 days Pre-Post Total Hip Replacement Lowers Pain, C-reactive Protein
By Peter A. McCullough, MD, MPH
The COVID-19 pandemic has prompted medical doctors who are are skilled in pharmaceuticals to expand their therapeutic armamentarium to include natural products with medicinal properties. Bromelain, a family of natural enzymes derived from the stems of pineapples has proteolytic, antifibrotic, anticoagulant, and anti-inflammatory properties.
In a prospective, randomized double-blind placebo-controlled trial, bromelain was combined with another enzyme trypsin and rutoside (rutin similar to quercetin), a flavonoid substance. The dose of bromelain ranged from 540 mg to 1080 mg per day. The objective results included a reduction in the inflammatory marker C-reactive protein, pain scores, and need for pain medication.
While we cannot tease out one component versus another, it is clear the combination was medicinally active in the human body. My inclination is to attribute most of the effect to the higher doses of bromelain.
It is reassuring to see RCT data on nutraceuticals and see they are influencing objective parameters. This strengthens support for McCullough Protocol Base Spike Detoxification, which includes nattokinase, bromelain, and curcumin. We cannot make therapeutic claims since large RCT’s have not been performed. In the meantime, our clinical observations are favorable in patients with post-acute sequelae after SARS-CoV-2 infection and COVID-19 vaccination.
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
A single IV Vitamin C infusion of has reduced pain from fractured ribs and other issues for my 102 year old mother considerably, I would say roughly 75%. Every doctor should know and use this but unfortunately very, very few do.
WHAT ABOUT A BLOOD TEST FOR SPIKE PROTEIN? I understand that without RCTs, it is impossible to make claims about the protocol you recommend. However, is it at all possible, outside of a clinical trial, to get a blood test for spike protein? How would one go about getting such a lab test--and would the results be meaningful as a measure of health risks?? I know that pre- and post-treatment testing is a weak for making claims of efficacy., but for those who have not yet started on the protocol, it would at least be better than nothing in terms of data. And in general, for anyone who has had the vaccine and is concerned, it would be great to know if there is spike in one's blood. I took two Moderna shots--in early 2021, after which I wised up. Before starting the protocol, I felt mental and physical fatigue, and now I don't. But of course I cannot claim that is what improved my energy level, because I also initiated other promising therapeutic around the same time (methylene blue, red light therapy). But please if you can tell us how to get a blood test for spike, I would appreciate it! Thanks to you and John for all you do.!