Randomized Trials Found Only Modest Reduction in Effect Size Compared to Non-Randomized Studies
New Analyses Suggests the Early COVID-19 Treatment Benefits Were Valid
By Peter A. McCullough, MD, MPH
I was rebutted in the US Senate on November 19, 2020, by Dr. Ashish Jha who was at the Brown School of Public Health at the time and later became the White House Coronavirus Coordinator. In response to my presentation of the McCullough Protocol for the early treatment of high-risk patients with acute COVID-19, he told America that his patients and doctors would only accept results from large, prospective randomized trials. By the way, the only COVID-19 products with such trials were mRNA vaccines.
Now a new analysis from Salcher-Konrad et al has found for drug therapies, that randomized trials yield a slightly more conservative estimate of effect size, specifically 19% lower. That means for observational, comparative studies with large effect sizes done in the field, the results are likely to be valid. For example, through 2020 Procter et al reported their results with early multidrug therapy for acute COVID-19: 87.6% and 74.9% reductions in hospitalization and death, respectively. That means at worst, the real effects were 70.9% and 60.7%—huge public health benefits were thrown aside by the soon-to-be vaccine promoter Jha.
If we have learned anything through the pandemic, we cannot wait for large randomized trials that will take years to complete and likely just confirm what doctors are observing in the field. Clinical judgment, empiricism, and observational data have crucial roles to play in future pandemics.
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
Peter, you know I think that observational versus RCT’s and their similar accuracy is not surprising. For instance the Mediterranean diet and its benefits was apparent to its consumers for centuries, the Asians with their white rice staple the same. Observing that the Amish kids who don’t take the US shot regimen do not have autism, that small practice general physicians knew remedies to help conquer various diseases and the general observation that those of us that consume non packaged “food” and soft drinks were generally healthier and slimmer than those that didn’t prove that our eyes are can make pretty good decisions.
For the entire medical industry to ignore and to reject any beneficial observational data with the excuse that only RCT’s would provide the answer to Covid was deliberate deceit and criminal.
Charlie DeSantis
For the same reason that Ivermectin and HCQ were blocked, inventory purchased by military, and our health 'officials' on media circuits to denounce any viable solution...other than the mRNA vaccines. It was a single orchestrated plan to defend an Emergency Use Authorization.