Real World Safety Data Indicate Drug-Drug Interactions with Paxlovid are Overstated
Minor Clinical Consequences with Concurrent Use
By Peter A. McCullough, MD, MPH
Paxlovid (nirmatrelvir tablets; ritonavir tablets), is the only oral agent officially endorsed by HHS, NIH, CDC, FDA for the ambulatory treatment of COVID-19. It has been undermined by concerns regarding drug-drug interactions (DDI) as well as “rebound” or an extension of the illness with abbreviated use. My clinical impression is that the drug is reasonably safe but only modestly effective. It appears to be slow-onset and only partially helpful as the an antiviral in the McCullough Protocol. As a clinician who has used all of the drugs in the protocol, my preferred antiviral is ivermectin 0.6 mg/kg per day for 5-30 days.
Bihan and coworkers analyzed the the BNPV pharmacovigilance database (N=12,179) which is administered by the Agence nationale desécurité du médicament et des produits de santé (ANSM), sponsored by the French Health Agency. There were 30 cases of DDI. Most of the interactions occurred in presumably transplant patients on tacrolimus or similar drugs. For the non-immunosuppressant cases the vignettes and outcomes were predictable and manageable.
In summary, despite theoretical concerns of DDI with paxlovid, the clinical reality for the brief course of treatment is reassuring. Despite its shortcomings, this drug can be used most appropriately in the context of a multidrug protocol in the treatment of acute ambulatory COVID-19. It should not be considered for monotherapy.
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Bihan et al, Nirmatrelvir/ritonavir (Paxlovid®): French pharmacovigilance survey 2022
As a layman, I cannot understand why anybody trusts HHS, NIH, CDC or FDA for a minute. They are the centers of the medical industrial complex, run by mad scientists like Anthony Fauci.
Peter,
You mentioned…
“..my preferred antiviral is ivermectin 0.6 mg/kg per day for 5-30 days”.
Could you list for everyone the drugs/treatments you would use next if you are treating a healthy person with these virus’ if one cannot get Ivermectin?
Hydroxychoroquine, quercetin, etc?
People have understandable fear of going anywhere near doctors and hospitals especially if you see the statistics I posted at Paul Alexander’s substack today. I will post in a separate comment after this one.
I for one, am thinking you will stay much healthier figuring this all out on your own consulting with doctors like you!
I wish we could clone you so there would be one of you in every city!
Thank you for sticking to the REAL science!
Regards,
Mother/Grandmother of 7 and counting