SARS-CoV-2 Spike Protein Found in the Human Nucleus
Designer Protein Breaks into Cellular Control Center and Poised to Wreak Havoc
By Peter A. McCullough, MD, MPH
In a recent paper by Sattar et al, in collaboration with the National Institutes of Health (NIH), it was discovered that both mRNA and Spike protein colocalized within the nucleus of human cells.[i]
The authors note this is unusual and appears to not rely upon the furin cleavage site which is necessary for Spike protein entry into the cell. It is important to note the context and the methods of this paper utilized SARS-CoV-2 and not mRNA or adenoviral DNA vaccines. However, the ramifications of this finding cannot be understated. Having both one of the most pathogenic and lethal proteins ever discovered found within the nucleus of human cells with its genetic code is a hair-raising discovery. A prior paper by Singh and Singh demonstrated Spike protein models anticipate an interaction with tumor suppressor genes P53 and BRCA1.[ii] Sattar now says this could indeed happen! Thus, Spike protein is at the scene of a crime—oncogenesis or the failure of immune surveillance against nascent cancer cells. Seneff et al have predicted that the Spike protein may be related to cell senescence and autophagy.[iii] This means more rapid aging of cells and then programmed cell death. I have had many patients ask me why they lose muscle mass and have hair loss after COVID-19 illness, these observations provide some explanatory basis for discussion at the cellular level. Finally and most disturbing, Nunez-Castilla et al of demonstrated homology of the Spike protein with about three dozen other human proteins.[iv] This explains why in the first place would the human nucleus allow entry of mRNA and Spike into the control center of the cell. The genetic code of SARS-CoV-2 was may have been intentionally “humanized” to make all of this happen by design. While Senator Rand Paul is doing a wonderful job staying focused on the US involvement in engineering of SARS-CoV-2, more in depth lines of inquiry are needed with preclinical scientists and officials from BARDA (US military research) and NIH to reveal how much they knew about mRNA, the Spike protein, and what it would do to human cells during SARS-CoV-2 infection and over the longer term.
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[i] Sattar S, Kabat J, Jerome K, Feldmann F, Bailey K, Mehedi M. Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS-CoV-2. bioRxiv [Preprint]. 2022 Sep 27:2022.09.27.509633. doi: 10.1101/2022.09.27.509633. PMID: 36203551; PMCID: PMC9536038.
[ii] Singh N, Bharara Singh A. S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. Transl Oncol. 2020 Oct;13(10):100814. doi: 10.1016/j.tranon.2020.100814. Epub 2020 Jun 30. PMID: 32619819; PMCID: PMC7324311.
[iii] Seneff S, Nigh G, Kyriakopoulos AM, McCullough PA. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs. Food Chem Toxicol. 2022 Jun;164:113008. doi: 10.1016/j.fct.2022.113008. Epub 2022 Apr 15. PMID: 35436552; PMCID: PMC9012513.
[iv] Nunez-Castilla J, Stebliankin V, Baral P, et al. Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins. Viruses. 2022;14(7):1415. Published 2022 Jun 28. doi:10.3390/v14071415
Thank you Dr McCullough for all you do. Subscribed.
Thank you Dr, McCullough,
The news keeps getting worse, and they continue to look the other way.
You continue to be my hero.
Thank you for exposing the ugly truth.