By Peter A. McCullough, MD, MPH
A recent review on postural orthostatic tachycardia syndrome (POTS) appeared in JAMA and stupendously failed to appreciate the ubiquitous SARS-CoV-2 Spike protein has made this medical term a household name. The piece had no practical suggestions and did not address the root cause.
Pandemic POTS: Viral & Vaccine Spike Protein, the Autonomic Nervous System, and a Rational Treatment Framework
Pandemic-era postural orthostatic tachycardia syndrome is not a mystery illness. It is a predictable, mechanistically coherent consequence of a specific antigen—the SARS-CoV-2 spike glycoprotein—interacting with three organ systems that share a common vulnerability: the heart, the vasculature, and the central and autonomic nervous systems. What follows is a synthesis of the pathophysiology and a practical, phenotype-driven treatment approach that prioritizes symptomatic control, preservation of functional capacity in young people, and root-cause mitigation of the antigenic trigger.
