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D M's avatar

DR ROGER MCFILLIN > Lindsey Clancy was placed on a psychiatric drug with no FDA approval for postpartum depression. Within 48 hours, she hadn't slept at all. Doctors abruptly stopped the drug, itself a dangerous move, then added a benzodiazepine and Benadryl on top of it.

Nobody had tested whether she could actually metabolize these medications. Specific genetic variants affecting drug metabolism are linked to homicidal thoughts, suicidal ideation, and akathisia, and clinical psychologist Dr. Roger McFillin says the onset "can happen immediately."

In under four months, Clancy went from one prescription to 13 drugs. "The more drugs that you enter into the system, the body, and then you stop them and you start them and you increase doses, you are increasing the likelihood of an adverse event," @DrMcFillin says, adding that "drug induced homicides do occur, especially within these psychiatric drugs.

AwakeNotWoke's avatar

The personnel who treated Lindsay were presented with evidence of possible psychosis very early on. Zoloft can trigger manic and mixed episodes in people with BPAD. A Nurse Practitioner suspected BPAD immediately when Lindsay reported severe insomnia in response to Zoloft.

It may or may not be relevant also that as a labor and delivery nurse she was vaccinated and then subjected to polypharmacy thereafter.

Annie Karns's avatar

AwakeNotWoke, when you or your loved one is ill, your experience as a physician or healthcare professional can go out of the window. It happened to me several to the consternation of my husband. It happened to my sister several times when her husband needed several emergency care visits. You become a patient.

sharon's avatar

DM, you said : "Nobody had tested whether she could actually metabolize these medications."

Can you explain how and when a doctor does this kind of test ?

I have never had a doctor show concern about any drug s/he was prescribing. Ever . Over my life time I have been to at least a 100 doctors .

Considering Clancy was a nurse , she had a good or great knowledge about drugs . She should have know better . Could it be she is evil along with all the other stated diagnoses?

D M's avatar

I didn’t say that. Dr Roger McFillin did.

sharon's avatar

Sorry DM, but have you ever heard such nonsense?

Dena's avatar

It’s not nonsense. I know individuals with health problems that decided to use some sort of DNA testing to help identify what medications could not be tolerated & may be causing their health issues. Very useful but not part of our medical / insurance coverage. The test is an out of pocket expense.

D M's avatar
23mEdited

Ok, Sharon. I’m not a doctor. But this is how you ask a question such as this, using Ai.

GROK > Expand on this …. Are there tests that can be run to find whether a person can metabolize certain medications, such as Specific genetic variants affecting drug metabolism that are linked to homicidal thoughts, suicidal ideation, and akathisia?

GROK >> I’ll look up pharmacogenetic testing for drug metabolism and any documented links between specific variants and those psychiatric side effects.

GROK >>> Yes. There are clinical tests that look at how a person metabolizes many psychiatric drugs.

They do not currently function as a reliable “will this person become homicidal or suicidal” screen.

They do identify genetic variants that change drug levels, and higher (or rapidly fluctuating) levels are one of the mechanisms proposed for akathisia, agitation, and, in some case series, suicidal or violent ideation.

What the tests actually measure

Most of the relevant tests are pharmacogenomic (PGx) panels focused on cytochrome P450 enzymes that break down antidepressants, antipsychotics, and related drugs:

Gene / Common phenotypes

CYP2D6

Poor / intermediate / normal / ultrarapid

CYP2C19

Poor / intermediate / normal / rapid / ultrarapid

CYP2B6

Variable

CYP2C9

Intermediate / poor

A poor metabolizer of a given enzyme typically gets higher blood levels of the parent drug at a standard dose.

An ultrarapid metabolizer may clear some drugs so fast they never reach a stable level (or, for prodrugs, convert them too aggressively).

Commercial panels (GeneSight, ClarityX Mindwell, Genomind, Tempus, hospital lab panels, etc.) usually use a cheek swab.

CPIC and some FDA labels already give dosing guidance for several of these gene–drug pairs.

FDA also publishes a table of pharmacogenetic associations. 

The claimed link to akathisia, suicidal ideation, and violence

The hypothesis is pharmacokinetic:

1. Variant alleles (especially loss-of-function alleles in CYP2D6 / CYP2C19 / CYP2C9) slow clearance.

2. Concurrent inhibitors (other antidepressants, some antibiotics, antifungals, grapefruit, etc.) can further “phenoconvert” a person toward poor-metabolizer status.

3. Resulting high or unstable levels increase risk of akathisia (inner restlessness that patients often describe as unbearable), agitation, insomnia, and emotional dysregulation.

4. Akathisia has long been associated with suicidal and, in forensic case series, violent behavior.

Supporting literature is mostly case series and forensic work, not large prospective trials:

• Lucire & Crotty (2011) and related papers described people who committed homicide or serious violence while on antidepressants (often prescribed for situational distress, not major depression).

Almost all had at least one variant CYP450 allele; many were also on interacting drugs.

Symptoms remitted after the drug was stopped. 

• A 2016 forensic paper and a 2021 comparative study reported higher rates of variant CYP alleles among people with medication-associated violence or “altered emotional states” (akathisia, agitation, suicidal ideation) than among controls. 

• A small youth study of escitalopram found slower CYP2D6 phenotype associated with higher akathisia scores, and certain HTR2A genotypes associated with higher self-injury / harm-to-others scores. 

Mainstream reviews note associations between CYP2C19/CYP2D6 poor-metabolizer status and higher drug exposure plus more adverse effects, and some papers mention possible relevance to antidepressant-induced suicidality.

They also emphasize that current CPIC/FDA guidelines do not treat PGx as a predictor of suicide or homicide. 

What guidelines actually support

• Supported: Use CYP2D6 and CYP2C19 (and sometimes CYP2B6) results to choose starting dose or an alternative drug for several SSRIs, SNRIs, TCAs, and some antipsychotics, because exposure differences are real and dose-related side effects are more common in poor metabolizers.

• Not supported as a standalone predictor: Using the same genes to say a person “will” or “will not” develop suicidal or homicidal ideation. The boxed warning on antidepressants for increased suicidality in people under 25 is population-level, not genotype-specific.

• FDA has repeatedly warned companies not to market combinatorial PGx tests as if they can predict response or specific psychiatric adverse events when that claim is not in the drug label. 

Practical limitations

• Phenoconversion is common: a genetically normal metabolizer can act like a poor metabolizer if they take a strong CYP2D6 inhibitor (paroxetine, fluoxetine, bupropion, some others).

• Panels differ in which alleles they test and how they bin recommendations; results are not interchangeable.

• Ultrarapid CYP2D6 status has been linked in some data to suicide/intoxication risk with certain prodrugs (e.g., codeine), which is a different mechanism from poor-metabolizer toxicity.

• Therapeutic drug monitoring (blood levels) plus clinical observation of akathisia remains more immediately useful than genotype alone.

Bottom line

Yes — PGx tests for CYP2D6, CYP2C19, and related genes are available and can identify people who are likely to run high (or unstable) levels of many psychotropics.

That pharmacokinetic difference is a plausible contributor to akathisia and, in published case series, to severe behavioral toxicity including suicidal and homicidal ideation.

It is not currently a validated screening test that can rule those outcomes in or out.

The most defensible use is still: if someone has had a severe activation/akathisia reaction, or is about to start a high-risk substrate, genotype plus a careful med review (and sometimes blood levels) can help choose a safer dose or a drug that uses a different pathway.

This is not medical advice; interpretation belongs with a clinician who can combine genotype, current medications, and symptoms.

https://grok.com/share/c2hhcmQtMw_baf78cd6-5f46-4971-b9e7-811ac2438345

Annie Karns's avatar

Yes. I have been on psychiatric meds but never had tests except for Lithium.

Steve Church's avatar

That is quite a story. Mr. Leake is reliable in his attentiveness to details. Incredibly sad.

CanadaChick's avatar

Certainly more questions than answers...but we know it isn't the prescriptions!

Mary's avatar

How do you know?

CanadaChick's avatar

That was sarcasm, friend.

Mary's avatar

Well, with all the hate directed at this woman, I just didn't know. I am very disheartened at the public backlash. So, I am sorry I misinterpreted.

CanadaChick's avatar

No apology necessary - you're right about the hate and I'm disheartened too. My comment was a nod to the medical industry saying for forty years "we don't know what causes autism but it's definitely not the vaccines!"

denise ward's avatar

Why do we shrug and accept that? Doesn't it make everyone want to spit chips like it does me? And why do people keep listening to news channels that never cover the death tolls from covid?

AwakeNotWoke's avatar

I suspect that most of those calling for her execution were very quiet when Chris Watts pleaded guilty to escape the death penalty.

From my observations these same morons also have no problem with the US deliberately targeting and executing a school full of young girls in Minab in Iran.

CanadaChick's avatar

I don't know the story of Chris Watts but the global cognitive dissonance and hypocrisy is staggering no matter the topic anymore.

AwakeNotWoke's avatar

Chris Watts murdered his pregnant wife Shannan and two young daughters, Bella (4) and Celeste (3), in Colorado in August 2018. He was having an intense affair with his coworker, Nichol Kessinger and strangled Shanann in their home then loaded her body into his truck, put his living daughters in the vehicle, and drove to an oil-and-gas work site. There, he buried his wife in a shallow grave and smothered both little girlsWatts later admitted that while committing the murders, all he could think about was that he was finally free to be with his mistress. Investigators concluded he viewed his pregnant wife and young daughters as financial and emotional liabilities preventing him from getting his clean slate.

Watts was pretty much the typical American male and before the murders, the family's life appeared idyllic on social media, filled with loving posts, videos, and declarations of a happy marriage.

Dan's avatar

No way can we forget or excuse the deaths of three innocent children. However, I remember when I was trying to quit smoking. Graduating to cigars, chewing tobacco, etc. wasn't working so I finally asked my MD at the time about it and got a Rx for Chantix. Whoa!!! I never got the urge to kill someone, but I had to stop after about five days. Incredibly bad dreams and urges.

Then there's those shooters. Every single case where they tell you whether or not the shooter was on prescription psychotropic drugs, they were.

So, yes, horrible what happened, but was she to blame or the assholes who gave her that evil stuff.

Phil Davis's avatar

The jury consisted of nine women and three men. What we haven't heard, or at least I haven't, is what happened during voir dire. I understand that only one juror, a man, refused to acquit. He held his ground, and that resulted in the mistrial. Although I don't know everything about this trial, I still salute this man.

Manuela's avatar

One person doing the right thing makes all the difference.

AwakeNotWoke's avatar

11 people did the right thing. It's almost by definition that the state failed to prove its case beyond reasonable doubt when 11 out of 12 were not convinced.

Phil Davis's avatar

Reasonable doubt about what? That she killed her children? No, not that. She did absolutely murder her children in cold blood. There is no doubt about that fact.

The real doubt should be whether she is using her insanity plea to stay out of prison.

I would also like to point out that the national media is all over this reasonable doubt issue, using it to incriminate a lone juror. Does that not give you pause that the media has taken a side? When the media start pushing a narrative, it almost always means it's propaganda.

AwakeNotWoke's avatar

If you drank Kool Aid given to you by Jimmy Jones and you gave some to your kids, or if someone spiked your drink with a powerful hallucinogenic drug, like the US did to some of its own population during MKULTRA, and you began having delusions and hallucinations afar your drink was spiked and you thought God or the Devil was commanding you to do something terrible and you did, most Americans would say you should be executed.

Well your own brain can manufacture substances similar to hallucinogenic drugs and some people may respond to polypharmacy and sleep deprivation in a similar way.

Manuela's avatar

This Is a nurse specializing in labor

and delivery. They only hire the best and brightest for those positions.

She is not stupid. She also knows how pharmaceuticals work. Any nurse will have the cognitive awareness and training to speak out and say, “My meds are not working; I need to get help.” She didn’t.

In a court with a case like this, the one who wins is usually the one who can afford the best attorneys. In her case, she had the media on her side in a court in one of the most Leftist states in our country. Please don’t try to pretend that justice happens in the courts. It doesn’t. And although I have Ivy League attorneys in my circles who attest to this from their daily experience, I don’t need an Ivy League trained attorney to tell me this.

Phil Davis's avatar

That means that anyone can get away with murder. My brain made me do it. You, I, or anyone else cannot know this woman's brain. What I am suggesting to you is that this lone juror was the one using reasonable doubt correctly. Even though reasonable doubt is used against a prosecutor's charges in court, this juror doubted the defense's insanity plea. I've been on plenty of juries and understand the judge's instructions before deliberations: any doubt about guilt requires acquittal. However, in Insanity defenses, one must also reasonably be sure the defendant is actually insane. This juror wasn't sure, and I applaud him for making this hard decision.

Dena's avatar

Find & watch what some of these female jurors are now publicly saying.

freelearner's avatar

Andrea Yates was also on so many rapidly-changing psychiatric meds that her psychiatrist should have been charged with criminal negligence and possibly something like accessory to manslaughter if such a thing exists.

I believe Big Pharma paid a number of influencers to inflame the debate on both sides -- with ridiculous women lamenting having children in extreme language, or filming themselves throwing ice cubes into bathtubs to express their rage at having small children -- and on the other side, men saying this just shows why women are irrational and shouldn't have the vote. All of this sound and fury to set everyone at each other's throats while the elephant in the room -- the fact that psychiatric meds clearly can cause homicidal behavior which would otherwise never have occurred -- walks silently out, unnoticed by most.

D M's avatar

Psychiatrist Dr Josef Witt-Doerring > Drawing on the medical record and the defense's filings, board-certified psychiatrist walks through the months leading up to that day: a mother who sought help for postpartum anxiety and depression, and a treatment path that escalated from Zoloft to a rotating "cocktail" of psychiatric medications, Prozac, Seroquel, amitriptyline and others as her condition worsened rather than improved.

https://youtu.be/WUSH0D9LjSA?is=RErnZixOjGRjC7yd

Dr Drew Show > Dr. Josef Witt-Doerring on SSRI Violence

https://www.youtube.com/live/t9Q0MqKR8wI?is=CA7ri_3b9PLIngqe

Daniel Kirsner's avatar

Dr Josef Witt-Doerring's videos are absolutely essential viewing for this case.

Nurse Michele's avatar

Nurse Michele’s thoughts on the Lindsay Clancy case…things that make you go…hmmm.

Just a couple of questions that seem reasonable for…Real Science to ask…

WHEN A MOTHER KILLS THREE CHILDREN, SHOULDN’T WE ASK -WHAT HAPPENED TO HER BRAIN?

https://x.com/nurse_michele/status/2096013742748115343?s=46

THE PSYCH-ALTERING POTENTIAL OF LINDSAY CLANCY’S PRESCRIBED PSYCHIATRIC MEDICATIONS: EFFECTS, CLEARANCE & WITHDRAWAL

https://x.com/nurse_michele/status/2097332874378633706?s=46

Dina's avatar

With all the family & doctors knowing she had severe mental health, many mental health breakdowns how could they possible leave her alone with her children, knowing what they knew.

This woman needed extensive long term care. At least 6 mo. to a year at a highly rated mental health care.

Annie Karns's avatar

You know, the Covid vaccine might have contributed. That’s a great insight.

Barbara Charis's avatar

Drugs wipe out the glands in the brain, which contribute to thinking, logic, learning, memory, emotional development, behavior and more. Doctors don't study nutrition and what happens, when food or substances enter into the bloodstream, through ingestion or injection. The bloodstream carries the substances in them through the entire body...and into the brain. The bloodstream is designed to carry nutrients to NOURISH the organs, glands and cells. Drugs do not nourish, they are toxic and will harm the glands and organs.. They negatively impact the glands in the brain causing brain-damage. In the last 75 years, people started going regularly to doctors for drugs and vaccines. The mental and physical health of the American people has declined greatly. America used to be #1 in World health. it is now in 47th Place. What can be done with someone who was put on many drugs, which creates brain-damage? Someone who has killed her own children. Lindsey can not be loosed in society. However, society is also to blame for promoting toxic drugs.

evergreen's avatar

Perhaps a new law might change the tide: prescriber of known psych meds shall be seated beside the defendant as a codefendant in such cases.

andy's avatar

Yankee respectability? What a hoot. Guffaw-ha-ha.

“Those are the ways of the Yankees …”

https://www.youtube.com/watch?v=kQiGgj5hwz0

Pharma Beads have far surpassed strong whiskey & the beady-eyed, having run out of injun-others to inebriate, pillage & murder, have squinted their sights elsewhere, everywhere.

But naiveté, credulity, gullibility, deference, submission, passivity & domestication are also complicit.

“Yes, Dr. Milgram, whatever you say, the banality of evil suits us just fine.”

Dark Beer Thoughts's avatar

She methodically and carefully and patiently murdered her 3 children... Hell is too good for her.

Mary's avatar

Thank you for not attacking Lindsay as so many others have who have no background in psychiatry and are literally jumping up and down insisting that she "premeditated" because she sent her husband out knowing she would do this. And based on "premeditation", they want a lifetime prison sentence. I have taken care of people this sick. People who were clearly not mentally competent and psychotic, but could answer questions, fill out forms, and appear normal. I don't care what legal charges in Massachusetts that her case will fit into. I understand 3 children were murdered. And despite it being one floor, she still ended up a paraplegic. The only reasonable thing to do is commit her permanently to a state mental hospital and provide her with the medical and psychiatric care she needs.

John Leake's avatar

An extremely confounding case in which everyone's conduct strikes me as odd. The throwing of a bunch of psychiatric drugs at people going through tough times strikes me as one of the greatest pathologies of what passes for rational medicine.

JanC1955's avatar

I believe her medical and psychiatric care should involve permanent sterilization. Immediately. It's too late for the three little souls whose lives she ended, but she can certainly be prevented from conceiving another child.

Annie Karns's avatar

You cannot sterilize a person without their consent. Sterilization is not the treatment. Her mental health is the problem confounded by the polypharmacy she received.

JanC1955's avatar

Her children did not give their consent. Murder was not the appropriate "treatment" for her "problems" with them. Their deaths were at her hand. Hopefully you won't forget those 3 little souls in your advocacy for the woman who took their lives. There are pictures of them everywhere on the internet. (Not here, but elsewhere.) Have a long look at them, and consider the possibility that there could be more of them. Their mother is only in her mid-30's.

evergreen's avatar

Did not follow at all. Saw headline and episode of def atty berating judge for holdout juror. Learned some details, nowhere enough to have opinion.

Leake lays out the highlights, and lo, she was a normal wife/mother who encountered conventional PPD, was prescribed, voluntarily committed for homicidal thoughts,.... and....people can't see the forest?

Annie Karns's avatar

What’s the forest? Pray tell?

evergreen's avatar

Wicked meds cut loose in bulk upon already mentally susceptible society.

If mind alteration is OK (e.g., giving psych meds), one would expect a less rational person on the other side, yes or no?

Bob Brown's avatar

Might checkout Jenna McCarthy's substack from Tuesday ("Patrick said"): https://jennasside.rocks/p/patrick-said?r=4h2vhs Maybe we don't actually know who killed the children given the details that she points out.