Risk of Alzheimer's Disease According to APOE Genotype
Widely Available Blood Test Gives You a "Heads Up"
By Peter A. McCullough, MD, MPH
Having two parents with Alzheimer’s disease has given myself and my siblings some advanced warning to evaluate and hopefully attenuate our risks of ending up in the same condition later in life. I’ve known for years that the APOE4 gene is the “Alzheimer’s gene” and have paid attention to research in this area. For reference, the normal haplotype is APOE3/E3.
I found a recent editorial in JAMA by Reiman et al very helpful:
In accordance with population-based longitudinal data from more than 10 000 persons who were initially aged 60 to 75 years and cognitively unimpaired at study entry, lifetime risk of developing MCI or dementia by age 85 years is approximately 10% to 15% for APOE4 noncarriers, 20% to 25% for heterozygotes, and 30% to 55% for homozygotes (Qian et al).8
So for all persons concerned, I order the APOE genotype blood test. Those who are APOE4/E4 I strictly advise against any further alcohol intake and refer them to Alzheimer’s prevention research centers where baseline neurocognitive function is assessed every five years and interventions can be tested. The key is to get the genetic test and act decades before the potential onset of the illness. So ask your doctor to order this test on the next visit. It only needs to be done once during your lifetime.
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Peter A. McCullough, MD, MPH
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Thank you. Perhaps this concept can be expanded to testing children for genetic predispositions to the inability to metabolize certain vaccine ingredients and other toxins as a "heads up". I'm all for finding genetic markers as this can be an indicator for things to avoid and making lifestyle changes. Where we get into trouble is when we try to modify the genome ourselves, intentionally with mRNA, or accidently with DNA contaminated products.
I am in the EU. Some time ago, I asked my doctor to include a Vitamin D level in my blood test. He was surprised, but did it. Next, I asked for a HOMA-IR test…..they do NOT perform this in my country…no lab, and even the diabetes foundation here indicates that this is not done. I can only imagine my doctor’s response when I ask for an APOE test.