39 Comments
User's avatar
Marmie's avatar

I have a question for either you or Dr McCullough. I have only heard positive or neutral information on DMSO from doctors (Dr Mercola being one positive!) and patients alike, until today in this article https://open.substack.com/pub/medicinegirl/p/disastorous-dmso?r=pfs0m&utm_medium=ios.

Do you have an opinion on its safety and effectiveness?

Expand full comment
John Leake's avatar

We will look into it! Please stay tuned!

Expand full comment
Gabriella's avatar

And Would love if you both could look into chlorine dioxide solution also.

Expand full comment
neener's avatar

My husband has had great results applying it for toenail fungus.

Expand full comment
Gabriella's avatar

I know A Midwestern Doctor has written about it, but his articles are so long I can’t get through them or they are behind a paywall. I’m aware others have written about it also. I’m looking for one source that can give best, simplest methods for using it. I’ve read/heard different products to purchase, different ways of mixing it, & more. I can’t keep track of it all. I know it has to be stored in certain types of containers and believe it has to be stored in frig and only lasts so long. My heads spinning when it comes to chlorine dioxide and DMSO. They both seem to be great and helpful products… I’m overwhelmed with info circulating & just wish I could go to or contact someone to help me know how to use them for myself and specific needs.

Expand full comment
Gabriella's avatar

I’ve also heard chlorine dioxide can help autism symptoms. I am interested in this also as my oldest son, 36, has now been diagnosed on the spectrum. Has struggled with ADHD, allergies, asthma, anxiety, depression, suicidal ideation as well.

Expand full comment
Allie's avatar

I remember when Dr. McCullough on his Outloud podcast he regularly touted ClO2, until he had a guest on the program, an occupational consultant for OSHA who recommended against it. I never heard him say another thing about it since.

Expand full comment
Gabriella's avatar

CI02? This is what?

Expand full comment
Allie's avatar

Chlorine dioxide (it’s not bleach), considered “the universal antidote.”

Expand full comment
Gabriella's avatar

Yes, I’m aware of chlorine dioxide not being bleach & as universal antidote. I didn’t know the acronym for it. So is that what you’re saying CI02 is chlorine dioxide? just to clarify.

Expand full comment
Mothertrucker's avatar

I’d really like clarification on the purported benefits of methylene blue.

I’ve read of many yet there are others out there claiming it’s actually akin to a neurotoxin.

Expand full comment
Barbara Charis's avatar

I use a pendulum (asking the Creator for guidance). I got a negative for methylene blue. My daughter bought some, but it went into the trash. I later read that there was mercury in it.

Expand full comment
Barbara Charis's avatar

Thanks for asking that question. I used it on my legs... the skin was scrapped off, when I hit the wrong button...and the treadmill accelerated...lost my balance and rode the tread to the floor. I did have a bad reaction... and wasn't sure what caused it. After the fact, i read on the label : Avoid contact with skin.

Expand full comment
Barbara Charis's avatar

Now, I am using it in a full glass of water orally and have no problems thus far In fact, the swelling in my right leg from my fall went down.

Expand full comment
Allie's avatar

I used to be a wound care specialist and I remember people were beginning to use it on wounds. There was a product called hydrogens blue that I used on my own infected skin biopsy site that was very effective. It acts like a wound antiseptic.

Expand full comment
Tony Oliver's avatar

all medications, herbs, tonics have their down side. That is why it is important to know the makeup and interaction details. The Midwestern Doctor on substack delves into this.

Expand full comment
Roisin Dubh's avatar

I had to stop using it, as it caused the most agonizing headache I ever experienced. I did a bit of research, and one in ten people can't use it for the same reason. I found a decades old bottle in my father's box, he was a dog breeder, I wish I could have asked him about it.

Expand full comment
Allie's avatar

John, you are one of the few Substackers who is willing to dialogue with your readers. Much appreciated.

Expand full comment
DM Brown's avatar

Midwest Doctor has a slew on info on DMSO!

Expand full comment
albert venezio's avatar

We do appreciate you John and Dr. McCullough as people who are very unique, good and courageous!

Expand full comment
RUTH DONOHUE's avatar

Hi John,

I very much enjoy your writing and feel it is a great opportunity for me to have a ring side seat with such athoughtful, well read, informed gentleman as yourself. My social circles would never reach to great people like yourself, Dr. McCollough, and Nick Hulscher. I read some of the other comments, and they confirmed my suspicion that many of us are finding it difficult to support the very many authors that working hard to warn us of various concerns. I think the end of summer, kids back to school, early september is a time to review, catch up, and clean up our adminsistrative lives. I bet that is why you saw a purge of sorts. Keep up your great work! I will appreciate most of the topics that capture your interest, and i appreciate having access to your perspective.

Ruth

Expand full comment
Zachary Guadamour's avatar

What thing you should focus on is the nutritional causes of chronic illness, and what you can do to correct them through proper diet and minineral and vitamin supplementation. Unfortunately, modern American "medicine" focuses more on masking symptoms and not getting at the unerlying cause of disease.

Expand full comment
Sheila's avatar

Great one! Like do we need that new fatty acid, C15?

Expand full comment
neener's avatar

More on developments, or non development in Lahaina!

Expand full comment
Dag Waddell's avatar

I hope you keep on the path you believe to be true and don’t adjust to suit readers’ preferences.

Expand full comment
Jennifer Jones's avatar

John Leake

I would appreciate your investigating and writing something about what will happen to the cities and DC that are being nicely cleaned up as ICE moves on to other cities. Will the cities be willing to or able to keep more undocumented criminals

out of their cities? Where are illegal criminals currently going currently, so that DC looks great and is currently safe? Will they start coming back? What do you think could be solutions? You could tie this topic in with your true crime writing.

Expand full comment
Tony Oliver's avatar

I really appreciate the insightful information John Leake provides on a variety of topics. I have learned so much. The stack of classical music was a bonus. The medical information has been helpful by providing facts and analysis. Have no idea how I happened on this substack, yet am grateful.

Expand full comment
Diedre Lavers's avatar

I have no suggestions as I like your site the way it is. Yours is the first thing I look for in the morning to read. I love the medical ( I’m retired pharmacist) and I love John’s thoughtful essays on other subjects. keep doing what you are doing. There is just so much to read these days. Too many choices. I’m trying to cut back but not on your site.

Expand full comment
Sukey Watson's avatar

Thank you John. In my comment yesterday I forgot to mention how much I appreciate that you bring up history and classical literature to illustrate your points. I haven’t read all that much classical literature and as a young g person history bored me; probably because it was presented so dryly as facts etc. to memorize with little or no context. That was probably by design because even then in the late 70s, early 80s, the controlling powers did not want us to have an uncontrolled view of history, but rather wanted to warp our minds to think in certain ways. So I vote to keep the historical and literary analogies coming our way.

Expand full comment
Michael Long MD's avatar

I love your work. Keep it up!👍🏼

Expand full comment
Brent McGregor's avatar

I've always found something prescient in these posts. The concept of compassion has weighed heavily on my mind lately. Then this. There are deep blessings for those who know and ask, "The Question".

Expand full comment
Sheila Barkofske's avatar

I didn’t comment on the previous post because I am fine with the substack as is, but a summary of the comments might be interesting.

Expand full comment
Douglas Sayers's avatar

Many thanks for all you do.

A couple of cautions that crossed my mind when considering your request for feedback:

Please, whenever possible, show real solidarity with others in the effort to bring integrity back to medicine and politics. IMA, Highwire / Siri, Kennedy, Malone, Paul Thomas, AFLDs ….We need to show our unity in the fundamental agreements when possible. It’s no time for petty professional pride or self promotion. Don’t let the marketing people run the show! Ratings be damned. Speak the truth no matter the cost.

I know it’s hard (John) but try to keep the ad hominem abusives to a necessary minimum. :)

One possible suggestion for future topics: Aim your investigative guns at the threat posed by big banks / federal reserve, BIS, and giant corporations. If an entity is too big to fail… it is too big. I smell a crypto / ai rat in the house.

Thanks again, I look forward to your articles.

DS

Expand full comment
Sheila's avatar

Ooh, the big banks! Yes!! See my recent article about why THAT topic rings true for me:

https://sheilamurrey.net/2025/09/08/integrating-the-spirals-why-i-might-be-a-conspiracy-theorist-part-1/

Expand full comment