While many people have had success losing weight with these drugs, a lot of doctors don’t seem to be aware or care that others have suffered very serious and long-lasting side effects.
I am in the latter class and went through “My year of living painfully,” as documented in my Substack article of that name. Thankfully, my symptoms finally did subside after almost a year, although many others have not been so fortunate.
I don’t know anything about the so-called best in class drug that the Good Doctor is touting here, however, I would urge great caution for anybody considering the use of any of this class of drugs!
Spot on! I am very disappointed in the endorsement for GLP1 that destroys muscle cells which have long term negative effects. My Gail was on Lilly's brand for 3 months and developed retinal inflammation if not corrected could lead to blindness. Lilly has pushed this side effect selling against their competition. Amazing gall! The Wellness Company benefits from Perk and can sell in directly to the patient, just as Lilly is doing with their GLP1. What should be promoted is healthy caloric intake, intermediate fasting and exercise. I will no longer subscribe to anyone who is pushing the Wellness Company agenda. I doubt this message will remain on the website, since my last message was deleted.
Hey Corrin, thanks for sharing your experience. And you’re spot on — these side effects are horrendous. I’ve covered GLPs almost two years ago — and the side effects are not worth it, nor the financial spend: https://unorthodoxy.substack.com/p/the-hidden-struggle-in-health-care
thanks, although my prescription was covered fully by insurance and didn’t cost me anything monetarily. What it cost me in pain and suffering was incalculable!
Dr. McCullough, I am a paid subscriber to your Substack. Your support for this new and unproven class of medications sounds quite similar to the statement, “take this shot and you won’t get Covid”. Followed by, “here’s my own company’s Covid shot that’s the best of ‘em all”. Not even a little info on muscle loss. Particularly, that muscle that beats in your chest that you spent a career thinking about. Even if the crap you’re selling might injure that? Super disappointing.
Unfortunately his article raises two problems. First, prescribing a pill that costs $6,000 per year enables people to continue their bad habits. It's like prescribing Narcan so addicts can continue and even expand their drug use while the rest of us pay the societal and monetary bill. Second, the motivations and conflicts that drive this recommendation ultimately should cause readers to question whether the doctor is a trusted source of information in future health crises. It's an unfortunate turn of events.
I’m afraid he might miss his Cardiologist salary, which I understand. With his encyclopedic mind, I think he can do better without having to peddle these products.
Dr. McCullough don’t be a shill. The ethical error you made in this article shows a blind spot a mile wide. Seems like you attack the jab when you don’t have a financial interest but conveniently look the other way when you do. No mention of side effects, which are subatantial and significant.
This is more evidence that financial interest determines ’medical ethics’. I expected better from you but it looks like putting patient well being above your getting paid is too big an ask. Please address this issue.
With all of the known risks and probably many still unknown for this class of medication, do you really want to go down this road, Dr. McCullough? Surely there are better, safer ways to lose weight that you could be highlighting, but they would not be sources of income for you. I see all of your infomercials on my favorite news channels and those advertisements implanted within what are supposed to be news and educational articles and I’m becoming increasingly disappointed in you. You have a right to earn a living after the COVID tyrants tried to take away your license, but, I think, you have gone too far. I’ll always respect and honor you for your original work in the COVID fight, but please be upright in choosing the path you go down.
The first question with any health issue is always to determine the true cause and then address that. The medication route for unwanted weight doesn't do either. Clearly many are eating too much and too much of the wrong "food," I wouldn't call a lot of what fills grocery shelves more than a food-like substance. I would say that there are three key elements. 1) Adopt a healthy mind frame about eating and snacking and use that to support new habits. Pay attention to the emotional aspect of eating. 2) Shift to a reasonable diet of real food. There is no one perfect diet for everyone--I would avoid all the people pushing their own version of "the" right diet, but real fresh food prepared in a healthy way is key and doesn't need to be difficult or time consuming. 3) Use an amenable program of diet and enjoyable exercise to gradually return the body to a healthy state. This needs to be a permanent shift.
There isn't just one way to do this. Dr. Gabriel Cousens has documented on film the power of diet with two benefits. In the first case, moving out of a diabetic metabolism--in just 30 days. Not only does metabolism improve but in a supervised way people were able to move off of multiple pharmaceuticals. Two, in another instance gradually moving out of a badly overweight state with a prolonged diet of fresh vegetable juices. Cousens is a great proponent of a raw food diet, but that isn't the only way. I would say that another important piece is cutting the consumption of...television. The commercials don't exactly promote real food, and also encourage a sedentary lifestyle.
There is no need for shaming anyone, just thoughtful support and a viable program, but the key ingredient is determination on the part of the individual, and no self-shaming either if the person falls off the program. Just love oneself and get back on the horse. Be part of a support group. Etc.
I agree with the sentiment exactly. I have great respect for the good doctor and will always be thankful for the pioneering work he did which cost him so much in his professional career.
nobody is perfect, however, and I disagree with the doctor with his advocacy of other pharmaceutical such as statins, and now these weight loss drugs.
What bothers me the most is he never seems to read the comments on his own Substack and responds only rarely
What seems to go un-considered is that the serum half-life of natural GLP-1 in the blood serum is less than 5 minutes, whereas these mimicking compounds hang around for days, up to a week (hence the weekly injection version). I’d be very suspicious this “overload” as the body sees it leads to down regulation of receptors, the latter in the brain being critical for mitochondrial energy modulation. Is this why the increased risk of ischemic optic neuropathy?
As a parallel, synthetic, but “bioidentical” erythropoietin produced quite a flurry of reports of great responses for anemia of chronic disease and that associated with congestive heart failure. There were minimal adverse effects, but it also had a short half life and injections were needed three or more times per week. “Inconvenient and costly.” So…longer lasting modifications of the hormone were developed and…started to show an increased stroke risk. This has lead to broad hesitancy to use any marrow stimulating approach, especially with chronic heart failure, though review of the data says the problem was only really associated eith the extended half-life artificial creation. I wonder if Dr. McCullough has thoughts on this. One must be VERY careful trying to cheat God’s Nature.
Significantly, pharma and obesity experts never mention that fact. Here's what you need to know. "Experimental and clinical intervention studies suggest that omega-6 and omega-3 fatty acids have opposing physiological and metabolic properties and elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, systemic inflammation and an increase in the tone of the endocannabinoid system. Overweight and obese individuals have higher levels of the arachidonic acid (AA) derived endocannabinoid N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and an altered pattern of receptor expression. Since endocannabinoids are products of dietary fats, modification of the omega-6 and omega-3 fatty acid intake modulates the endocannabinoids, with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) displacing AA from cell membranes, reducing AEA and 2-AG production, resulting in decrease in appetite and food intake leading to weight loss." https://www.ocl-journal.org/articles/ocl/full_html/2020/01/ocl190046s/ocl190046s.html
For the scientifically curious, I suggest you do some 'adipose tissue arachidonic acid' web searches in conjunction with any sort of mental pr physical malady that comes to mind. Examples:
Peter, Some of the information in this stack is meritorious and appreciated. This particular piece smacks of snake oil salesmanship...very disappointing. Here is what DeepResearch (correctly) says about this piece:
The claims made in Dr. McCullough's article that "DROP" from The Wellness Company is an oral, needle-free, peptide form of retatrutide with a superior safety and efficacy profile are unsubstantiated and highly improbable based on current scientific and regulatory realities.
There is no verifiable, official product information from The Wellness Company for a product named "DROP" that is explicitly marketed and sold as oral retatrutide with listed ingredients and supporting clinical data.
The Wellness Company primarily markets dietary supplements, which are not subject to the same rigorous FDA approval process as pharmaceutical drugs.
The development of oral peptide drugs like retatrutide is scientifically challenging, and there is no credible evidence that The Wellness Company possesses such a product that has undergone appropriate clinical testing.
The FDA has explicitly stated that retatrutide cannot be legally used in compounding, making any such product illicit.
Please pull this and go back to publishing things which can be trusted.
Ah, oral peptide drugs. Typically, research into this class of drug aims at regulating some aspect of arachidonic metabolism or eicosanoid production. It may be far more effective, not to mention far less expensive, to correct metabolic problems by reducing arachidonic acid intake. Unfortunately, the fields of nutrition and medicine have not deliberately experimented with reduced arachidonic acid intake. Excerpt from a 2007 commentary: "Nevertheless, it is important to keep in mind that, just because there is little biological impact of an increase in arachidonic acid intake or status, there may still be significant benefit from a decrease in its intake or status." https://pubmed.ncbi.nlm.nih.gov/17705889/
Excerpt from a 1996 symposium on arachidonic acid: "Excessive signaling of arachidonic acid (AA) metabolites has been associated with various chronic degenerative or autoimmune diseases, and intervention with the metabolism of AA is widely employed therapeutically in these afflictions. In essence, AA is the most biologically active unsaturated fatty acid in higher animals. Its concentration in membranes and its magnitude of effects depend on its amount, or that of its precursors and analogues, in the diet. The tendency of the field of nutrition to ignore the role of dietary AA will optimistically be reversed in the future." The article also said, "The underlying rationale for this symposium is that dietary AA is perhaps the single most important nutritional determinant in regulating AA levels in Americans. This may ultimately account in part for the striking differences in chronic diseases between strict vegetarians and the bulk of the omnivorous population." https://pubmed.ncbi.nlm.nih.gov/8642436/
(2010) "Chicken meat with reduced concentration of arachidonic acid (AA) and reduced ratio between omega-6 and omega-3 fatty acids has potential health benefits because a reduction in AA intake dampens prostanoid signaling, and the proportion between omega-6 and omega-3 fatty acids is too high in our diet." https://pubmed.ncbi.nlm.nih.gov/20398309/
(2011) "Eicosanoids are major players in the pathogenesis of several common diseases, with either overproduction or imbalance (e.g. between thromboxanes and prostacyclins) often leading to worsening of disease symptoms... Even though the underlying biochemical mechanisms have been thoroughly studied for more than 30 years, neither the agricultural sector nor medical practitioners have shown much interest in making practical use of the abundant high-quality research data now available." https://pubmed.ncbi.nlm.nih.gov/21247506/
(2023) “Poultry meats, in particular chicken, have high rates of consumption globally. Poultry is the most consumed type of meat in the United States (US), with chicken being the most common type of poultry consumed. The amounts of chicken and total poultry consumed in the US have more than tripled over the last six decades… Limited evidence from randomized controlled trials indicates the consumption of lean unprocessed chicken as a primary dietary protein source has either beneficial or neutral effects on body weight and body composition and risk factors for CVD and T2DM. Apparently, zero randomized controlled feeding trials have specifically assessed the effects of consuming processed chicken/poultry on these health outcomes.” https://pubmed.ncbi.nlm.nih.gov/37630747/
All I see from Doctor McCullough lately are advertisements for his overpriced pills. To some money is everything. I think he's a brilliant doctor but he has dollar signs in his eyes.
Can we all agree that the reason obesity occurs in individuals, in the vast majority of cases, is their diet. The best approach would be to prevent obesity to start with, but for the most part we are faced with patients requiring treatment because they are already obese.
The reason most diets fail to generate weight loss is hunger. The GLP prevents hunger, hence people do not eat as much.
It appears they will induce weight loss regardless of the diet they are on, or if they exercise any beyond the activities of daily living. Can we also agree that the most rapid and effective weight loss method is just to stop eating, that is fasting. I guarantee everyone will lose weight. The question is "why don't people do this?" Of course you may answer by saying that this is the same reason other diets do not work, that is people get hungry.
But wait a minute, we know that after a few days your body begins to metabolize fat and protein such that your body's demand for energy is being met. Hunger is driven by the body's demand for energy. Why then can we just not eat for a few days till this demand is met?
No we get to the real problem, which is psychological. People to seem to have an instinct to avoid not eating, perhaps related to the drive to prevent starvation. In any case, it is difficult to get people to fast.
This difficulty can be reduced by the GLP drugs, and I think starting the drugs, perhaps only the lower dose oral drugs will suffice, and at the same time starting fasting will enable more to succeed.
Of course, like any weight loss diet, after you lose the weight, you must then go on a different diet than the one that made you fat to begin with.
Or, perhaps you should just stay on GLP for the rest of your life, but as many have commented, this is not a normal nor healthy situation. Better to just get on a better diet. Of course you then must know what this is. Kelly Gregg Diet and Health
you always provide research evidence. So why not this time?
(I write to express my concern).
(1) You have not provided, nor can I find elsewhere, any evidence to support sale or use of DROP (which you purport to be an oral formulation of the Retratudide polypeptide injectable). You have not provided, nor can I find, the published human or laboratory animal clinical trials, nor can I find research proofs of physiological or pharmacological effects. In short no evidence for this product.
(2) Why are you realing out lots of product names? Is it to somehow impress the science-illiterate masses?
(3) The GLP1 drug revolution is in its infancy. Early versions and products are neither safe nor sufficiently tolerated to be effective in the long term, (and should never have been licensed, IMO, but greed and corruption took over). Therefore, consumer caution is warranted.
(This reference is long, but necessary if you want to go into GLP1 with your eyes open).
Subsequent GLP1's (especially some of the oral ones which have been/are now being researched with intent to obtain licensed approval) show promise and I acknowledge that your product (DROP) may indeed prove to be safe and effective.
Are you trying to steal an unfair march on these (at this time) more ethical companies, who are providing research data to the public and the authorities? - May God forbid!
Have we learned nothing from the past five years?
Dr McCullough, please don't betray our trust and your good name!
Nothing is worth that.
EVIDENCE FIRST, SALES AND PRESCRIPTIONS SECOND!
::::::::::::::::::::::::::::::::::::
To fellow readers.
To help fellow readers keep up to date (and avoid the more muddied of research waters and PR campaigns), I suggest you go to Yandex.com and search:-
Retatrutide oral version
GLP1 oral version
(and then try the same on Google).
Finally, to understand investor motivations, you might go to
(if I have unfairly missed other players, I apologise)
Bruce Thomson
retired veterinarian
As a final comment. Don’t be in a hurry to buy. If you absolutely want to buy, contact Dr MCullough direcly first, and ask for his evidence (he may know more than he is willing to publish, at this stage).
While many people have had success losing weight with these drugs, a lot of doctors don’t seem to be aware or care that others have suffered very serious and long-lasting side effects.
I am in the latter class and went through “My year of living painfully,” as documented in my Substack article of that name. Thankfully, my symptoms finally did subside after almost a year, although many others have not been so fortunate.
I don’t know anything about the so-called best in class drug that the Good Doctor is touting here, however, I would urge great caution for anybody considering the use of any of this class of drugs!
Remember, there is no such thing as a free lunch!
Spot on! I am very disappointed in the endorsement for GLP1 that destroys muscle cells which have long term negative effects. My Gail was on Lilly's brand for 3 months and developed retinal inflammation if not corrected could lead to blindness. Lilly has pushed this side effect selling against their competition. Amazing gall! The Wellness Company benefits from Perk and can sell in directly to the patient, just as Lilly is doing with their GLP1. What should be promoted is healthy caloric intake, intermediate fasting and exercise. I will no longer subscribe to anyone who is pushing the Wellness Company agenda. I doubt this message will remain on the website, since my last message was deleted.
Hey Corrin, thanks for sharing your experience. And you’re spot on — these side effects are horrendous. I’ve covered GLPs almost two years ago — and the side effects are not worth it, nor the financial spend: https://unorthodoxy.substack.com/p/the-hidden-struggle-in-health-care
thanks, although my prescription was covered fully by insurance and didn’t cost me anything monetarily. What it cost me in pain and suffering was incalculable!
Dr. McCullough, I am a paid subscriber to your Substack. Your support for this new and unproven class of medications sounds quite similar to the statement, “take this shot and you won’t get Covid”. Followed by, “here’s my own company’s Covid shot that’s the best of ‘em all”. Not even a little info on muscle loss. Particularly, that muscle that beats in your chest that you spent a career thinking about. Even if the crap you’re selling might injure that? Super disappointing.
Studies have come to show that people on GLPs may have their heart muscle shrink as well — so your comments here are spot on a mark!
Yep! They don’t care! The life is shortened but they cash in!
It does smack of a money making scheme. I am disappointed and doubt I will renew my $100 a year membership to the Wellness Company.
Same here! He has lost his compass. So has Dr. Alexander!
Unfortunately his article raises two problems. First, prescribing a pill that costs $6,000 per year enables people to continue their bad habits. It's like prescribing Narcan so addicts can continue and even expand their drug use while the rest of us pay the societal and monetary bill. Second, the motivations and conflicts that drive this recommendation ultimately should cause readers to question whether the doctor is a trusted source of information in future health crises. It's an unfortunate turn of events.
I’m afraid he might miss his Cardiologist salary, which I understand. With his encyclopedic mind, I think he can do better without having to peddle these products.
Dr. McCullough don’t be a shill. The ethical error you made in this article shows a blind spot a mile wide. Seems like you attack the jab when you don’t have a financial interest but conveniently look the other way when you do. No mention of side effects, which are subatantial and significant.
This is more evidence that financial interest determines ’medical ethics’. I expected better from you but it looks like putting patient well being above your getting paid is too big an ask. Please address this issue.
He has lost his compass! So has Alexander who pushes Wellness Company!
With all of the known risks and probably many still unknown for this class of medication, do you really want to go down this road, Dr. McCullough? Surely there are better, safer ways to lose weight that you could be highlighting, but they would not be sources of income for you. I see all of your infomercials on my favorite news channels and those advertisements implanted within what are supposed to be news and educational articles and I’m becoming increasingly disappointed in you. You have a right to earn a living after the COVID tyrants tried to take away your license, but, I think, you have gone too far. I’ll always respect and honor you for your original work in the COVID fight, but please be upright in choosing the path you go down.
The first question with any health issue is always to determine the true cause and then address that. The medication route for unwanted weight doesn't do either. Clearly many are eating too much and too much of the wrong "food," I wouldn't call a lot of what fills grocery shelves more than a food-like substance. I would say that there are three key elements. 1) Adopt a healthy mind frame about eating and snacking and use that to support new habits. Pay attention to the emotional aspect of eating. 2) Shift to a reasonable diet of real food. There is no one perfect diet for everyone--I would avoid all the people pushing their own version of "the" right diet, but real fresh food prepared in a healthy way is key and doesn't need to be difficult or time consuming. 3) Use an amenable program of diet and enjoyable exercise to gradually return the body to a healthy state. This needs to be a permanent shift.
There isn't just one way to do this. Dr. Gabriel Cousens has documented on film the power of diet with two benefits. In the first case, moving out of a diabetic metabolism--in just 30 days. Not only does metabolism improve but in a supervised way people were able to move off of multiple pharmaceuticals. Two, in another instance gradually moving out of a badly overweight state with a prolonged diet of fresh vegetable juices. Cousens is a great proponent of a raw food diet, but that isn't the only way. I would say that another important piece is cutting the consumption of...television. The commercials don't exactly promote real food, and also encourage a sedentary lifestyle.
There is no need for shaming anyone, just thoughtful support and a viable program, but the key ingredient is determination on the part of the individual, and no self-shaming either if the person falls off the program. Just love oneself and get back on the horse. Be part of a support group. Etc.
I agree with the sentiment exactly. I have great respect for the good doctor and will always be thankful for the pioneering work he did which cost him so much in his professional career.
nobody is perfect, however, and I disagree with the doctor with his advocacy of other pharmaceutical such as statins, and now these weight loss drugs.
What bothers me the most is he never seems to read the comments on his own Substack and responds only rarely
What seems to go un-considered is that the serum half-life of natural GLP-1 in the blood serum is less than 5 minutes, whereas these mimicking compounds hang around for days, up to a week (hence the weekly injection version). I’d be very suspicious this “overload” as the body sees it leads to down regulation of receptors, the latter in the brain being critical for mitochondrial energy modulation. Is this why the increased risk of ischemic optic neuropathy?
As a parallel, synthetic, but “bioidentical” erythropoietin produced quite a flurry of reports of great responses for anemia of chronic disease and that associated with congestive heart failure. There were minimal adverse effects, but it also had a short half life and injections were needed three or more times per week. “Inconvenient and costly.” So…longer lasting modifications of the hormone were developed and…started to show an increased stroke risk. This has lead to broad hesitancy to use any marrow stimulating approach, especially with chronic heart failure, though review of the data says the problem was only really associated eith the extended half-life artificial creation. I wonder if Dr. McCullough has thoughts on this. One must be VERY careful trying to cheat God’s Nature.
GLP-1 receptor agonists modulate endocannabinoid system activity. (web search - GLP-1 receptor agonist endocannabinoid system)
Significantly, pharma and obesity experts never mention that fact. Here's what you need to know. "Experimental and clinical intervention studies suggest that omega-6 and omega-3 fatty acids have opposing physiological and metabolic properties and elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, systemic inflammation and an increase in the tone of the endocannabinoid system. Overweight and obese individuals have higher levels of the arachidonic acid (AA) derived endocannabinoid N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and an altered pattern of receptor expression. Since endocannabinoids are products of dietary fats, modification of the omega-6 and omega-3 fatty acid intake modulates the endocannabinoids, with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) displacing AA from cell membranes, reducing AEA and 2-AG production, resulting in decrease in appetite and food intake leading to weight loss." https://www.ocl-journal.org/articles/ocl/full_html/2020/01/ocl190046s/ocl190046s.html
RFK Jr. has only a social media understanding of seed oil issues. Chip Paul and the autor of the above article are trying to bring the endocannabinoid system into the public eye. https://www.kxan.com/business/press-releases/ein-presswire/795302194/experts-sound-alarm-on-dangerous-omega-6-and-omega-3-imbalance-in-u-s-food-supply/
For the scientifically curious, I suggest you do some 'adipose tissue arachidonic acid' web searches in conjunction with any sort of mental pr physical malady that comes to mind. Examples:
adipose tissue arachidonic acid metabilic syndrome
adipose tissue arachidonic acid brease cancer
adipose tissue arachidonic acid prostate cancer
adipose tissue arachidonic acid depression
adipose tissue arachidonic acid autism
adipose tissue arachidonic acid fatty liver disease
Peter, Some of the information in this stack is meritorious and appreciated. This particular piece smacks of snake oil salesmanship...very disappointing. Here is what DeepResearch (correctly) says about this piece:
The claims made in Dr. McCullough's article that "DROP" from The Wellness Company is an oral, needle-free, peptide form of retatrutide with a superior safety and efficacy profile are unsubstantiated and highly improbable based on current scientific and regulatory realities.
There is no verifiable, official product information from The Wellness Company for a product named "DROP" that is explicitly marketed and sold as oral retatrutide with listed ingredients and supporting clinical data.
The Wellness Company primarily markets dietary supplements, which are not subject to the same rigorous FDA approval process as pharmaceutical drugs.
The development of oral peptide drugs like retatrutide is scientifically challenging, and there is no credible evidence that The Wellness Company possesses such a product that has undergone appropriate clinical testing.
The FDA has explicitly stated that retatrutide cannot be legally used in compounding, making any such product illicit.
Please pull this and go back to publishing things which can be trusted.
Ah, oral peptide drugs. Typically, research into this class of drug aims at regulating some aspect of arachidonic metabolism or eicosanoid production. It may be far more effective, not to mention far less expensive, to correct metabolic problems by reducing arachidonic acid intake. Unfortunately, the fields of nutrition and medicine have not deliberately experimented with reduced arachidonic acid intake. Excerpt from a 2007 commentary: "Nevertheless, it is important to keep in mind that, just because there is little biological impact of an increase in arachidonic acid intake or status, there may still be significant benefit from a decrease in its intake or status." https://pubmed.ncbi.nlm.nih.gov/17705889/
Excerpt from a 1996 symposium on arachidonic acid: "Excessive signaling of arachidonic acid (AA) metabolites has been associated with various chronic degenerative or autoimmune diseases, and intervention with the metabolism of AA is widely employed therapeutically in these afflictions. In essence, AA is the most biologically active unsaturated fatty acid in higher animals. Its concentration in membranes and its magnitude of effects depend on its amount, or that of its precursors and analogues, in the diet. The tendency of the field of nutrition to ignore the role of dietary AA will optimistically be reversed in the future." The article also said, "The underlying rationale for this symposium is that dietary AA is perhaps the single most important nutritional determinant in regulating AA levels in Americans. This may ultimately account in part for the striking differences in chronic diseases between strict vegetarians and the bulk of the omnivorous population." https://pubmed.ncbi.nlm.nih.gov/8642436/
(2010) "Chicken meat with reduced concentration of arachidonic acid (AA) and reduced ratio between omega-6 and omega-3 fatty acids has potential health benefits because a reduction in AA intake dampens prostanoid signaling, and the proportion between omega-6 and omega-3 fatty acids is too high in our diet." https://pubmed.ncbi.nlm.nih.gov/20398309/
(2011) "Eicosanoids are major players in the pathogenesis of several common diseases, with either overproduction or imbalance (e.g. between thromboxanes and prostacyclins) often leading to worsening of disease symptoms... Even though the underlying biochemical mechanisms have been thoroughly studied for more than 30 years, neither the agricultural sector nor medical practitioners have shown much interest in making practical use of the abundant high-quality research data now available." https://pubmed.ncbi.nlm.nih.gov/21247506/
(2023) “Poultry meats, in particular chicken, have high rates of consumption globally. Poultry is the most consumed type of meat in the United States (US), with chicken being the most common type of poultry consumed. The amounts of chicken and total poultry consumed in the US have more than tripled over the last six decades… Limited evidence from randomized controlled trials indicates the consumption of lean unprocessed chicken as a primary dietary protein source has either beneficial or neutral effects on body weight and body composition and risk factors for CVD and T2DM. Apparently, zero randomized controlled feeding trials have specifically assessed the effects of consuming processed chicken/poultry on these health outcomes.” https://pubmed.ncbi.nlm.nih.gov/37630747/
All I see from Doctor McCullough lately are advertisements for his overpriced pills. To some money is everything. I think he's a brilliant doctor but he has dollar signs in his eyes.
What are the effects on mood from using these drops?
Can we all agree that the reason obesity occurs in individuals, in the vast majority of cases, is their diet. The best approach would be to prevent obesity to start with, but for the most part we are faced with patients requiring treatment because they are already obese.
The reason most diets fail to generate weight loss is hunger. The GLP prevents hunger, hence people do not eat as much.
It appears they will induce weight loss regardless of the diet they are on, or if they exercise any beyond the activities of daily living. Can we also agree that the most rapid and effective weight loss method is just to stop eating, that is fasting. I guarantee everyone will lose weight. The question is "why don't people do this?" Of course you may answer by saying that this is the same reason other diets do not work, that is people get hungry.
But wait a minute, we know that after a few days your body begins to metabolize fat and protein such that your body's demand for energy is being met. Hunger is driven by the body's demand for energy. Why then can we just not eat for a few days till this demand is met?
No we get to the real problem, which is psychological. People to seem to have an instinct to avoid not eating, perhaps related to the drive to prevent starvation. In any case, it is difficult to get people to fast.
This difficulty can be reduced by the GLP drugs, and I think starting the drugs, perhaps only the lower dose oral drugs will suffice, and at the same time starting fasting will enable more to succeed.
Of course, like any weight loss diet, after you lose the weight, you must then go on a different diet than the one that made you fat to begin with.
Or, perhaps you should just stay on GLP for the rest of your life, but as many have commented, this is not a normal nor healthy situation. Better to just get on a better diet. Of course you then must know what this is. Kelly Gregg Diet and Health
EVIDENCE FIRST, SALES AND PRESCRIPTIONS SECOND!
Dear Dr McCullough,
you always provide research evidence. So why not this time?
(I write to express my concern).
(1) You have not provided, nor can I find elsewhere, any evidence to support sale or use of DROP (which you purport to be an oral formulation of the Retratudide polypeptide injectable). You have not provided, nor can I find, the published human or laboratory animal clinical trials, nor can I find research proofs of physiological or pharmacological effects. In short no evidence for this product.
(2) Why are you realing out lots of product names? Is it to somehow impress the science-illiterate masses?
(3) The GLP1 drug revolution is in its infancy. Early versions and products are neither safe nor sufficiently tolerated to be effective in the long term, (and should never have been licensed, IMO, but greed and corruption took over). Therefore, consumer caution is warranted.
Read:
https://www.midwesterndoctor.com/p/the-great-ozempic-scam-and-safer
(This reference is long, but necessary if you want to go into GLP1 with your eyes open).
Subsequent GLP1's (especially some of the oral ones which have been/are now being researched with intent to obtain licensed approval) show promise and I acknowledge that your product (DROP) may indeed prove to be safe and effective.
Are you trying to steal an unfair march on these (at this time) more ethical companies, who are providing research data to the public and the authorities? - May God forbid!
Have we learned nothing from the past five years?
Dr McCullough, please don't betray our trust and your good name!
Nothing is worth that.
EVIDENCE FIRST, SALES AND PRESCRIPTIONS SECOND!
::::::::::::::::::::::::::::::::::::
To fellow readers.
To help fellow readers keep up to date (and avoid the more muddied of research waters and PR campaigns), I suggest you go to Yandex.com and search:-
Retatrutide oral version
GLP1 oral version
(and then try the same on Google).
Finally, to understand investor motivations, you might go to
https://www.google.com/finance/
And search (separately):
Eli Lilly, Viking Therapeutics, Novo Nordisk
(if I have unfairly missed other players, I apologise)
Bruce Thomson
retired veterinarian
As a final comment. Don’t be in a hurry to buy. If you absolutely want to buy, contact Dr MCullough direcly first, and ask for his evidence (he may know more than he is willing to publish, at this stage).
Bruce Thomson
retired veterinarian