20 Comments
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Corrin Strong's avatar

i’m glad you at least mentioned some of the dangers of these drugs, although you seem to gloss over them as being a small portion. I may be in that small minority, but my short experience with Ozempic was disastrous leading to almost a year of abdominal pain.

I found that most doctors were under the impression that as soon as you stopped taking them any side effects would end. Unfortunately that is not true!

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Thomas A Braun RPh's avatar

They bury the info about the long term side effects that create illness and shorter life spans. When 2/3 weight lost is from loss of muscle cells speaks volumes about what the long term side effects will be. Disappointed that Dr. M is pushing this! So obesity is down, but what illnesses are up because of GLP!?

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Corrin Strong's avatar

I didn’t actually lose any weight at all during my short trial, but that didn’t prevent me from getting a whole range of long-lasting bad side effects

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James Jones's avatar

thanks Corrin; very valuable to hear from someone who has taken the drug; and to hear the reality of harm can be like. I hope you are healing now.

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AMV's avatar

How about instead using daily exercise, diet control with less sugar/carbs and more healthy veggies, fruits and proteins! Cut out the junk food, fast food and over eating. It works with willpower, persistence and goals. Weight loss drugs are necessary for some people, but I hear many GLP-1 users experience negative side effects. More profit for big pharma, for sure.

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BlueCapitalist's avatar

Anyone who does a keto/carnivore style of diet will loose fat, gain lean body mass and optimize their overall health.

I do not support this fad of drugs that cause gastroparesis. Yes, I personally know several people who have had year to life long obesity who have had massive weight loss over the last 3 years.

I have a close acquaintance who has maintained a loss of over half her body weight. This seems great but I see what she eats for lunch; half a twix bar and a couple of bites of mashed potato or mac & cheese. If she eats more than this volume she will have nausea and vomiting due to the gastroparesis.

People withe severe gastroparesis from diabetic neuropathy will have also loose weight and their a1c will improve..

So after 30 or 40 years of surgically cutting out or rerouting food around the stomach or putting a fabricated band around the stomach to limit what can be consumed the stomach is now being chemically paralyzed. And this is a big medical advance....

Stop eating toxic garbage from the grocery store, plant a garden, get a some chickens and eat real food.

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James Jones's avatar

thanks for emphasising gastroparesis

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DC's avatar

As a medical professional any drop in obesity we are seeing is just temporary in my opinion. In my observations in practice as soon as these glp-1's are stopped the weight piles on and then some. The rapid weight loss people often experience leads to loss of muscle mass as well which sets people up for rapid weight gain when they are stopped. These drugs are a lifelong commitment. Patient's rely on the drug and do not tend to change habits or mind set and when the insurance cuts them off because their BMI is "at goal" the only option is to pay out of pocket up to a thousand of month for brand name or hundreds of dollars a month for compounded for the rest of their life. I'm not even mentioning the side effects on the gastrointestinal system people experience. We also cannot forget the thyroid cancer that was seen in the clinical trials either. I warn patients about all of this and if they choose to still use them at least they were properly informed of the risks.

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Rebekah Paparella's avatar

Dr.Bryan Ardis raised concerns that ozempic is made with Gila monster venom which paralyzes the stomach muscle. He added that nobody suffers from a deficiency of Gila monster venom. I have a relative who has some bad side effects currently which is sadly not surprising.

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Allie's avatar

Byetta (exenatide), I believe, was the first GLP-1 agonist used clinically. The manufacturers did not hide the fact that it made use of gila monster venom. It was no secret. Many drugs come from natural sources. Dr. Ardis has a habit of trying to scare you that snake venom and Gila monster venom are surreptitiously being put in drugs. If a long chain protein shares an amino acid sequence with snake venom, then he suggests that manufacturers are obtaining venom from snakes and putting it in their product. Ardis is a chiropractor, not a medical doctor or a pharmacologist. I have listened to his podcast and it is clear to me that he has no chemistry or pharmacology background. It is clear to me that there is much that he does not understand. I’m just saying that you need to do your own research and not assume the credibility of anyone. A person could be correct on some things and totally off the mark on other things.

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Rebekah Paparella's avatar

Thanks for the reply. For myself, I have no trust in ingesting any type of animal venom and suspect many consumers will feel the same if only they knew the source and ingredients.

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Roisin Dubh's avatar

Also risk of blindness. Why not use portion control instead?

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Barbara Charis's avatar

I went through my teen years and up to 39 years of age, at 150 pounds (5'3") , because I had no real nutritional knowledge. Once I started eating, as our Creator intended our species to eat, the weight came off. I started eating natural unprocessed food and today I weigh 110 pounds. I also exercise daily doing an hour of fast walking at 91 years young.

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The Situation Room's avatar

There are many problems with GLP-1 drugs.

And there is the problem. Major ADRs incoming. No indemnity for these injections.

Side effects being ignored again:

* Shrinks muscle including heart

* Nausea - slows stomach emptying

* Vomiting - violent/persistent

* Diarrhoea - depleted nutrients

* Pancreatitis

* Gastroparesis - stomach paralysis

* Bowel obstruction

* Cancer - pancreas and thyroid.

This will put an enormous strain on health services.

In US, 1800 in class action re side effects especially permanent blindness.

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Maria's avatar

This is insane - I get that getting the weight off is necessary, but the concept that you go on and off the drug because there's been no behavior modification, is a real problem. Who ever believes weight loss should be easy is lazy. There's no easy day, only yesterday was easy. It's all about behavior modification, and there's the rub.

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Roisin Dubh's avatar

I know someone who went on it for a short time, he lost a ton of weight, he did not regain most of it back, he hired a nutritionist. I know someone else who has also lost a ton of weight but remains on the drug. He so far has no side effects. The problem is, side effects often don't show up for a long time such as cancer. It is a tempting solution, for me at least, but I don't trust the safety of drugs in general. Also, some people who take it, give credit for their weight loss to diet and exercise and don't emphasize the real reason is the drug.

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Monterey's avatar

A family member was on this for a while. Made the person dizzy at unpredictable times. Very bad

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James Jones's avatar

yup' you wanna lose some muscle mass; lose some bone density, well, roll up; roll up; free also with this offer is pancreatitis and a host of other exciting adverse effects; (what we doctors call HARM ..)

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Dr. K's avatar

Gentlepeople, Both of your pictures are dead links...not a great way to sell stuff...

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Roisin Dubh's avatar

If we use portion control and healthy choices, why use GLP agonists?

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