Hi. There’s a bunch of democrats taking over the public section of this platform with lots of bad negativity… some hostility and videos. Moms against ice and some others. I hope you guys can do something about it.
Yesterday, Vaccines: Mythology, Ideology and Reality arrived. I plan on reading it as quickly as possible...and leaving a review on Amazon. It was already given 5 stars by my daughter who got it for me.
Dr. McCullough - I am looking forward to reading your book, but wanted to get your attention regarding Nattokinase. I had an extremely serious adverse effect from Nattokinase, and you should recommend greater caution when you recommend Nattokinase. As for me, it has been as serious as Coumadin (not in a good way) - and I had no idea. I was initially taking, sometimes your Spike Support, one serving daily, and more often Doublewood's Nattokinase 4000 fu. But more recently, I had read a preprint of a new article suggesting higher doses may be better, so I increased the dose, not quite to the 1,000 fu every day but heading in that direction. Before an out of state trip to a conference, I stopped taking it entirely, but 4 days after that, returning home, I had a fall at the airport, badly injuring one knee which was horrifically bruised and swollen. A PA at an urgent care referred me to see an orthopedic surgeon 2 days later. He took one look and asked if I was taking Coumadin or Aspirin. That was when I realized that it was the Nattokinase that had made me so vulnerable to bleeding. The surgeon knew that the amount of bleeding into my knee was unusual and he correctly assumed it must have been associated with a "blood thinner." That very same day, I had some esophageal bleeding which I have never had before, though I do have an esopheageal "ring" which I have had for years. Three or four days later, I had some additional new bleeding in my foot for no reason that I know of. I asked Google Gemini about side effects of Nattokinase, particularly regarding clotting / bleeding, and learned what perhaps you already know:
"Research suggests that the half-life of nattokinase in humans is approximately 8 hours.
Some sources also mention that its activity can be maintained for an 8-12 hour period, and peak blood concentrations are typically reached around 2-4 hours after oral administration." [My comment - But, it's not just the half life to be concerned about as further below, again, which I assume you know.]
Continued comment from Gemini:
"It's important to note that while the half-life refers to the time it takes for half of the substance to be eliminated from the body, the biological effects of nattokinase (like its fibrinolytic activity) may extend beyond its direct presence in the bloodstream, due to its influence on other factors in the body."
I asked: Can you tell me anything further about how long its activity could persist especially regarding the effect on blood clotting?
Gemini: "You're right to ask about the persistence of nattokinase's effects beyond its direct half-life in the bloodstream, especially concerning blood clotting. Here's what the research suggests:
"While the half-life of nattokinase in the blood is about 8 hours, its beneficial effects on blood clotting mechanisms can persist for a longer duration. This is because nattokinase doesn't just act directly; it also influences the body's own systems involved in blood clot breakdown."
"Here's a breakdown of how its activity persists:"
"Direct Fibrinolysis: Nattokinase directly breaks down fibrin, a key protein in blood clots. Studies indicate that this direct effect begins relatively quickly, often within 2 hours of ingestion, reaching peak activity around 4 hours, and then gradually starts to wear off after 8 hours."
"Indirect Fibrinolysis and Anticoagulation: Nattokinase works through several indirect mechanisms that contribute to its prolonged effect on blood clotting:"
"Activation of Plasminogen Activator (t-PA): Nattokinase can promote the release of tissue plasminogen activator (t-PA) from endothelial cells, which then converts inactive plasminogen into active plasmin. Plasmin is the body's primary enzyme for dissolving clots."
"Degradation of Plasminogen Activator Inhibitor-1 (PAI-1): PAI-1 is an inhibitor of t-PA. By degrading PAI-1, nattokinase effectively "removes the brakes" on the body's natural clot-dissolving system, allowing t-PA to be more active."
"Influence on Blood Viscosity: Nattokinase has been shown to reduce whole blood viscosity (or thickness), which can improve blood flow and reduce the tendency for clots to form. This effect contributes to its overall anti-clotting properties."
"Reduction of Clotting Factors: Some studies have shown that consistent nattokinase supplementation (e.g., daily for several weeks) can reduce certain blood clotting factors, such as Factor VII and Factor VIII, which are involved in the coagulation cascade. This suggests a more sustained influence on the blood's clotting potential over time, beyond just the immediate presence of the enzyme."
"How long can these effects persist?"
"While a single dose might show direct fibrinolytic activity for about 8 hours, the more profound and long-term benefits related to overall cardiovascular health, including reduced blood pressure and improved blood viscosity, are observed with regular, consistent supplementation over weeks or months."
"For example, clinical studies have shown reductions in blood clotting factors after eight weeks of daily nattokinase intake. The continuous influence on the body's own fibrinolytic system and blood viscosity means that the beneficial anti-clotting effects are not just tied to the acute presence of nattokinase, but rather to a sustained modulation of the body's hemostatic balance."
"Important Note:"
"It's crucial to understand that while nattokinase shows promise, more extensive clinical trials are still needed to fully understand its long-term safety and efficacy, especially when used with other medications that affect blood clotting."
"Always consult with a healthcare professional before taking nattokinase, especially if you are on blood-thinning medications (like warfarin, aspirin, or other anticoagulants/antiplatelets) or have any bleeding disorders, as it can significantly increase the risk of bleeding. You may need to stop taking nattokinase prior to any scheduled surgery."
I think because of the several years of suppression of excellent meds like Ivermectin, which is so safe it seemingly does not even need medical monitoring, many people have become accustomed to taking medications and supplements with less reliance on physicians who primarily peddled toxic vaccines during the entire pandemic, and some of us don't like to go to physician's offices because most physicians were forced by government mandates to take the shots and now may still be shedding, and the people in the waiting room may be shedding. So I didn't recognize any reason to go to a primary care nurse practitioner who possibly has never heard of Nattokinase, to monitor my use of Nattokinase. But now it seems like it would have been a great idea to monitor some of the labs to make sure that Nattokinase was not causing some serious abnormalities regarding clotting. I have no doubt it dissolves spike protein and has many other benefits, but there is also a serious downside. I'm glad I didn't hit my head when I fell, as that may have caused a massive brain bleed. But this hemarthrosis in my knee is at the moment quite a bad enough problem. (I do have the orthopedic surgeon and a gastroenterologist looking after me, but it is concerning that I have had additional bleeding even a week or more after I had stopped Nattokinase; I've never had a bleeding / clotting disorder, and it seems that this is probably a major factor in my experience, particularly in light of what Google Gemini has said.)
A bad thing about supplements is, supposedly the are safe enough to be taken without prescription - but I think not always - and there is no official FDA approved label to go to, to compare the adverse effects of the supplement with the adverse events of a placebo. There are no official warnings to read. Many supplements are safe enough for anyone to take without any monitoring, but I have not been taking any blood thinners other than Nattokinase - which I didn't know was a potent blood thinner that could knock out my Factor VIII etc. I'll probably never take it again, though if I would have realized, I would have gotten some lab monitoring, and taken a pause or decreased the dose if lab results were abnormal. The thing is, though, if I had gone to a nurse practitioner, and NPs are who seem to provide most of the primary care in my area, I feel sure they would not have had any idea of what to monitor - I find the NPs in my area have rather limited knowledge and skill, many are quite young and there is only so much that can be taught and learned in 18 months of medical school. I am actually a health professional, but my specialty is not cardiology, hematology or Covid, and I didn't know that Nattokinase could do this. It would be a service if the Wellness Company would educate to some extent about the beneficial effects as well as precautions appropriate to Nattokinase. Such as not taking it if one is taking a blood thinner, and I think, monitoring labs perhaps infrequently, just to make sure the dosage being used isn't getting labs dangerously out of range.
Martha72- thank you for this detailed response and I’m so glad you did not knock your head and bleed out. You lived to create this response to nattokinase consumption and I hope AI can access this text in future for people who want to know about nattokinase. I think AI Gemini and others do NOT have access to Substack texts.
I’m trying to find out how much nattokinase to take to break down the spike proteins after three vaccinations. Is it a one time course that is needed, or do we need nattokinase for life? Or do we need it for a three month stretch then take a break for a year? How does it work?
It is interesting that nattokinase reduces blood pressure as a blood thinner! Very useful information. But it sounds like one needs to follow through with blood tests every three months(?) to be sure not to over do it.
This is not my speciality, and I can't give general recommendations. I wish Dr. McCullough would say, "Ask your primary doctor to check D-dimer levels" or whatever they use to check for spike so you know if that is improving, AND I wish he would say "if you are taking nattokinase, talk to your primary care professional and ask about blood monitoring such as tests x, y, and z." I would not give personal medical recommendations online like this, but I can't really even give general recommendations - I'm sure not everyone has these effects because so many of the studies say "no side effects!" but - I didn't have the side effects until I fell, then I had all that bleeding into my knee - and there are people who might have had a lot of bruising after an accident who would not connect the dots to the nattokinase, both patients and providers - I never studied nattokinase in medical school, and I also have never managed patients on coumadin or nattokinase in my particular speciality, so I don't know. I would suppose if you check blood tests after a couple weeks or so, and again in 3 months - if it is staying the same and the dose is the same, I don't know, maybe quarterly for a year and if the labs are staying normal and there are no side effects, maybe just annually - but I don't know for sure which tests to do. Also, it is recommended that you stop nattokinase in advance of surgery - now, it is emergency surgery, your stuck with whatever it is, but for elective surgery that you are planning, I read a week or two for nattokinase, and both Google Gemini and I reasoned it out and thought two weeks ought to be sufficient, for me, I had some additional bruising show up on my foot for no reason at about the two week point, I can't guarantee that two weeks is adequate, but I think so - Anyway, if you have a good primary physician and you show them what I wrote or ask Gemini yourself, hopefully your doctor will know what labs to check. It is unfortunate that the only meds we are taught about in med school or PA school etc. are meds on which pharma can make money, and then there are other potentially useful meds that people take that health professionals are never taught about at all, and basically if it is something that pharma is not making money on, we are not taught about it. We're taught only about FDA-approved meds, and there are other things that people take - and the health professionals are uninformed and often have to say "I don't know" and then they are very uncomfortable about it because we don't know, but we're still likely to be held responsible if something goes wrong with your health. So - I suppose the best thing to do is to get with a telemed doctor from what used to be the FLCCC - they have a list of doctors who follow their Covid protocols, it's now the Independent Medical Alliance at https://imahealth.org/ and they have lists of providers so you can find someone in your state - IF your own primary doctor doesn't want you to take nattokinase or does not know how to monitor it, I would think (hope) that one of the IMA doctors would know. As for Gemini, the thing about AI, no, they would not have read substack, but they read pretty widely in their training and Gemini gives references for what it finds for me - but I try to verify because they give the warning that AI can make mistakes, and I have seen a few - and I correct it and show additional information so that the AI will know better another time. So - just now I thought - I should ask Gemini (who I find to be the most useful for me) about the labs. I will paste that in as a separate reply in case this is helpful. If you have a primary care doctor, you can discuss with your doctor, or you can find a potential doctor through the IMA as above or - it normally would involve an office visit or virtual office visit with a professional who can order the labs.
This is NOT "medical advice" but rather, just education / information and to get actual medical advice on this requires a visit with an MD, DO, PA or nurse practitioner. This, below, is a copy and paste from Google Gemini Pro 2.5 in answer to my question about blood tests that should be done to monitor someone if taking nattokinase. I pointed out that some health care practitioners may not be very familiar with nattokinase. Here's Gemini:
You're right to be concerned about monitoring someone taking nattokinase, even though it's an over-the-counter supplement. Nattokinase has fibrinolytic (clot-dissolving) and anticoagulant (blood-thinning) properties, which can increase the risk of bleeding, especially if combined with other medications that affect clotting. Healthcare providers who are not familiar with this supplement might not know what to monitor.
Here's information on labs that may be considered useful to monitor someone taking nattokinase to assess for bleeding/clotting disorders:
Key Labs to Consider for Monitoring Bleeding/Clotting Risk:
Prothrombin Time (PT) / International Normalized Ratio (INR):
What they measure: PT measures how long it takes for blood to clot, and INR standardizes this measurement, especially important for those on warfarin. While nattokinase doesn't directly act on the Vitamin K clotting cascade like warfarin, some studies have monitored INR in patients taking nattokinase, particularly if they are also on anticoagulants.
Why it's useful: A prolonged PT/elevated INR could indicate increased bleeding risk.
Activated Partial Thromboplastin Time (aPTT):
What it measures: aPTT measures the time it takes for blood to clot via the intrinsic and common pathways of coagulation.
Why it's useful: An increased aPTT could also suggest an increased bleeding tendency.
D-dimer:
What it measures: D-dimer is a protein fragment produced when a blood clot is broken down by fibrinolysis. Elevated D-dimer levels indicate that clot breakdown is occurring.
Why it's useful: Nattokinase is known to enhance fibrinolysis. An increase in D-dimer could indicate that the nattokinase is actively breaking down fibrin, which is its intended effect, but also underscores its potential impact on the clotting system.
Fibrinogen:
What it measures: Fibrinogen is a protein that is converted to fibrin, which forms the meshwork of a blood clot.
Why it's useful: Nattokinase directly degrades fibrin and may lower fibrinogen levels. Significantly reduced fibrinogen levels could contribute to an increased bleeding risk.
Platelet Count and Function Tests:
What they measure: Platelet count determines the number of platelets in the blood. Platelet function tests (e.g., platelet aggregation studies) assess how well platelets are working.
Why it's useful: While nattokinase's primary action is on fibrinolysis, it has also been reported to have anti-platelet effects. Monitoring platelet count and function could be important, especially if someone is also taking antiplatelet medications like aspirin.
Important Considerations for Healthcare Providers:
Baseline Labs: It's crucial to obtain baseline blood tests before someone starts taking nattokinase to establish their normal clotting profile.
Concomitant Medications: This is perhaps the most critical factor. Nattokinase can significantly increase the risk of bleeding when taken with other medications that thin the blood, including:
Anticoagulants: Warfarin (Coumadin), direct oral anticoagulants (DOACs) like apixaban (Eliquis), rivaroxaban (Xarelto), dabigatran (Pradaxa), edoxaban (Savaysa), and heparin.
Other natural supplements with blood-thinning properties: Garlic, ginger, ginkgo biloba, fish oil (omega-3 fatty acids) in high doses, vitamin E.
Surgical Procedures: Nattokinase should be discontinued at least two weeks before any surgical procedure (including dental surgery) to minimize bleeding complications.
Bleeding History/Disorders: Individuals with a history of bleeding disorders (e.g., hemophilia), hemorrhagic stroke, or active bleeding should generally avoid nattokinase.
Clinical Symptoms: Beyond lab tests, it's vital to monitor for clinical signs of bleeding, such as:
Easy bruising
Nosebleeds
Bleeding gums
Prolonged bleeding from minor cuts
Unusual or heavy menstrual bleeding
Red or black stools (indicating gastrointestinal bleeding)
Dark urine
Severe headaches (could indicate intracranial bleeding)
Unexplained dizziness or weakness
Disclaimer: This information is for educational purposes and should not be considered medical advice. Anyone taking nattokinase, especially if they have underlying health conditions or are on other medications, should be closely monitored by a qualified healthcare professional who can determine the appropriate monitoring strategy based on their individual circumstances.
dr mccullough ~ i suffered a terrible vaccine reaction in 2021 and your spike support and written material were both helpful in my recovery. as a result i was happy to be one of the first to reply to john leake's appeal to readers to give a review on amazon. and as much as i am grateful for your work, i must point out that i find it hard to believe you would approve of misrepresentation of products at twc. ultimate spike has on the label "4x more nattokinase" when it simply does not. it has exactly the same amount per capsule (100 mg), the same number of capsules per jar (120) and it recommends taking twice as much (4 caps) per dose as compared to regular spike (2 caps) which only equates to 2x as much per dose. it costs $22.50 more for a bottle that lasts half as long. that false advertisement makes me question other products with apparently excessive pricing: $124.00 for toothpaste, $499.99 for weightloss drops and $599.99 for a parasite cleanse!
i wrote to twc and received an automated reply that didn't deal with the issue, then wrote a note to john in response to his appeal for support for your book... crickets. so i am writing to you. i hope you care enough to look into it and at least press them to correct the false advertising. as for me, i'm shopping elsewhere from now on.
ps - i had to buy a subscription just to get you this message.
Jef how much nattokinase does one have to take to break down the spike proteins after the Covid vaccines? Is it a one time dose of 30 days or do we have to take nattokinase everyday for the rest of our lives? Is it true that bromelaine in pineapple breaks down the mRNA? Is one pineapple enough to breakdown the mRNA? Or is pineapple now needed every day for the rest of our lives? (Which of course is very hard to sustain). Are you”spike proteins the same as mRNA? I’m not getting answers even when I read the material but you seem to know from experience the hard way.
hey dana ~ hope you are doing ok. just so it's clear, i'm not a doctor, not that it would automatically qualify me as to knowing what i'm talking about! however, regarding how much nattokinase to use or for how long depends on your own symptoms and toxicity. being that nattokinase thins the blood, as martha made clear in her comment, be sure that you don't have a problem there. i didn't and had no problems when taking it. i would say that using the product you choose according to directions makes the most sense and to take it for two to four weeks and see how you feel. it could be you need more or not. it also might help in conjunction with other support mechanisms such as bromelaine (yes it does help with spike) or ivermectin or quercetin, etc. you could use spike support from twc or alternatively you could use zstack or zspike or both from zstacklife.com. there is no nattokinase in either of those products and they still serve the same purpose. i was in terrible shape with myelitis (spinal inflamation) and a long list of symptoms that occurred as well. i found dr. sayed haider at mygotodoc who prescribed ivermectin, fluvoxamine, prenisone, nac, and vitamins, and i got nattokinase on my own and after two months at the recommended dosage i was feeling significantly better. it took me a couple of months to come around from excruciating disabling pain to tolerable limits without pain killers.
regarding mrna and spike, it's my understand thus far that toxic lipid nano particles deliver synthetic mrna (not like our own) to the cells and express the toxic spike protein and cause our immune system to respond by attacking our own tissues. apparently there is no virus involved, just a synthetic bioweapon meant to maim and kill. and being that this nanotech is now in our air, water, soil and food, including all other species, we will be combatting it into the forseeable future. however, i personally don't like the notion of supplementing my system constantly. i take my supplements for a two to three weeks and if i'm feeling well i stop for a time. i don't like to idea of juicing up my system constantly, i like to find my own stasis, to hold my own and not rely on supplementation, but instead just try to eat well and get regular exercise, which used to be skiing, biking, hiking, etc, but now is just walk the dog, but i'm still working on it.
there's lots of great people to read: sasha latypova, midwestern doctor, dr. anita baxas, christine massey, dr. william makis, doc malik, dr sam bailey, dr joseph mercola, dr sayed haider, dr tenpenny, the forgotten side of medicine, superspreader, etc., all on substack. endless info with them. i have also been following dr ardis online, using his edta for detox, and just got zeolite capsules through dr andrew kaufman at mendicamentum authentica for detox as well. i like to switch things up and not use one thing too much. presently i'm doing a detox following protocol 1000 using chlorine dioxide. it's weird, i smell chlorine all day long, but i want to see what happens.
i hope some of this helps and hope you are well, or on your way to feeling well. it's hard to feel positive in a world where the powers that be are making efforts to harm us, but i believe there are also many people making an honest effort to make the world a better place and help each other to heal, despite our limitations and personal biases. peace...
Hi there just looking for some advice… when i got the booster about a year ago two days later my conjecture is that i started having a cytokine storm which in emergency was going out of my brain can’t explain the feeling…kind like feeling manic, losing my mind,about to faint,delirious and nearly died with doctors sadistically smiling almost hoping i would die but i didn’t somehow…a week later i looked at discharge papers and had a CRP of 92 with anything over 50 considered an emergency either sepsis or systemic inflammation..they gave me no prednisone so a new MRI showed four large glioses and glial scarring which must have been from the vaccine and malicious failure to treat …anyway over next few months realised i had nearly died over ten times by a very serious form of epilepsy called status epilepticus and myoclonic seizures i was forced to diagnose through obvious systems as doctors or many of them know jack shit nor do they care…my question is that i feel pretty fine but since the spike proteins circulate throughout the body and brain for life would a spike detox still help
Too bad, but I'm disappointed in the interviewer who did not embark at all on the "Mythology and Ideology" subjects--the crucial sociological aspects many of us want to know about.
Exactly what are the driving forces behind the public's irrational beliefs about vaccines? Fortunately John, (towards the 30 minute mark) had a chance to compare the seemingly startling powers of vaccines to the "act of falling in love"--to which I assume means feeling safe and cared for, etc. Now, we are making sense if we want to somehow overcome the heavy lead fortress of unconscious beliefs that are imprisoning the mind.
The interview was mechanistic in that it just covered physiology and legislature--things most of us know about (Flexner Report, GAVI, DARPA, SV40, DNA plasmids..), which is not bad in itself, but far from being educational about mass hysteria.
The Polio Vaccine was not a effective of safe. Read A Midwestern Doctor substack on Polio. My much older than me cousin was incapacitated by the polio vaccine having to use crutches thru HS. He still cannot run.
If I tell you over and over again that you will get scarlet fever, at some point you will probably get scarlet fever. If I tell you over and over again that you will get covid, at some point you probably will get covid. If I then give you a 'shot' and tell you that this is going to help, you're going to believe it enough that it will. Though in some cases it will not.
There is a special place in Hell for those who profiteer off the childhood “injection” schedule. See the Book under “millstones”.
Hi. There’s a bunch of democrats taking over the public section of this platform with lots of bad negativity… some hostility and videos. Moms against ice and some others. I hope you guys can do something about it.
We can spread the only true #Covid sudit that Peter peer Reviewed and lauded:
https://WHOtoSTOP.com
Yesterday, Vaccines: Mythology, Ideology and Reality arrived. I plan on reading it as quickly as possible...and leaving a review on Amazon. It was already given 5 stars by my daughter who got it for me.
Dr. McCullough - I am looking forward to reading your book, but wanted to get your attention regarding Nattokinase. I had an extremely serious adverse effect from Nattokinase, and you should recommend greater caution when you recommend Nattokinase. As for me, it has been as serious as Coumadin (not in a good way) - and I had no idea. I was initially taking, sometimes your Spike Support, one serving daily, and more often Doublewood's Nattokinase 4000 fu. But more recently, I had read a preprint of a new article suggesting higher doses may be better, so I increased the dose, not quite to the 1,000 fu every day but heading in that direction. Before an out of state trip to a conference, I stopped taking it entirely, but 4 days after that, returning home, I had a fall at the airport, badly injuring one knee which was horrifically bruised and swollen. A PA at an urgent care referred me to see an orthopedic surgeon 2 days later. He took one look and asked if I was taking Coumadin or Aspirin. That was when I realized that it was the Nattokinase that had made me so vulnerable to bleeding. The surgeon knew that the amount of bleeding into my knee was unusual and he correctly assumed it must have been associated with a "blood thinner." That very same day, I had some esophageal bleeding which I have never had before, though I do have an esopheageal "ring" which I have had for years. Three or four days later, I had some additional new bleeding in my foot for no reason that I know of. I asked Google Gemini about side effects of Nattokinase, particularly regarding clotting / bleeding, and learned what perhaps you already know:
"Research suggests that the half-life of nattokinase in humans is approximately 8 hours.
Some sources also mention that its activity can be maintained for an 8-12 hour period, and peak blood concentrations are typically reached around 2-4 hours after oral administration." [My comment - But, it's not just the half life to be concerned about as further below, again, which I assume you know.]
Continued comment from Gemini:
"It's important to note that while the half-life refers to the time it takes for half of the substance to be eliminated from the body, the biological effects of nattokinase (like its fibrinolytic activity) may extend beyond its direct presence in the bloodstream, due to its influence on other factors in the body."
I asked: Can you tell me anything further about how long its activity could persist especially regarding the effect on blood clotting?
Gemini: "You're right to ask about the persistence of nattokinase's effects beyond its direct half-life in the bloodstream, especially concerning blood clotting. Here's what the research suggests:
"While the half-life of nattokinase in the blood is about 8 hours, its beneficial effects on blood clotting mechanisms can persist for a longer duration. This is because nattokinase doesn't just act directly; it also influences the body's own systems involved in blood clot breakdown."
"Here's a breakdown of how its activity persists:"
"Direct Fibrinolysis: Nattokinase directly breaks down fibrin, a key protein in blood clots. Studies indicate that this direct effect begins relatively quickly, often within 2 hours of ingestion, reaching peak activity around 4 hours, and then gradually starts to wear off after 8 hours."
"Indirect Fibrinolysis and Anticoagulation: Nattokinase works through several indirect mechanisms that contribute to its prolonged effect on blood clotting:"
"Activation of Plasminogen Activator (t-PA): Nattokinase can promote the release of tissue plasminogen activator (t-PA) from endothelial cells, which then converts inactive plasminogen into active plasmin. Plasmin is the body's primary enzyme for dissolving clots."
"Degradation of Plasminogen Activator Inhibitor-1 (PAI-1): PAI-1 is an inhibitor of t-PA. By degrading PAI-1, nattokinase effectively "removes the brakes" on the body's natural clot-dissolving system, allowing t-PA to be more active."
"Influence on Blood Viscosity: Nattokinase has been shown to reduce whole blood viscosity (or thickness), which can improve blood flow and reduce the tendency for clots to form. This effect contributes to its overall anti-clotting properties."
"Reduction of Clotting Factors: Some studies have shown that consistent nattokinase supplementation (e.g., daily for several weeks) can reduce certain blood clotting factors, such as Factor VII and Factor VIII, which are involved in the coagulation cascade. This suggests a more sustained influence on the blood's clotting potential over time, beyond just the immediate presence of the enzyme."
"How long can these effects persist?"
"While a single dose might show direct fibrinolytic activity for about 8 hours, the more profound and long-term benefits related to overall cardiovascular health, including reduced blood pressure and improved blood viscosity, are observed with regular, consistent supplementation over weeks or months."
"For example, clinical studies have shown reductions in blood clotting factors after eight weeks of daily nattokinase intake. The continuous influence on the body's own fibrinolytic system and blood viscosity means that the beneficial anti-clotting effects are not just tied to the acute presence of nattokinase, but rather to a sustained modulation of the body's hemostatic balance."
"Important Note:"
"It's crucial to understand that while nattokinase shows promise, more extensive clinical trials are still needed to fully understand its long-term safety and efficacy, especially when used with other medications that affect blood clotting."
"Always consult with a healthcare professional before taking nattokinase, especially if you are on blood-thinning medications (like warfarin, aspirin, or other anticoagulants/antiplatelets) or have any bleeding disorders, as it can significantly increase the risk of bleeding. You may need to stop taking nattokinase prior to any scheduled surgery."
I think because of the several years of suppression of excellent meds like Ivermectin, which is so safe it seemingly does not even need medical monitoring, many people have become accustomed to taking medications and supplements with less reliance on physicians who primarily peddled toxic vaccines during the entire pandemic, and some of us don't like to go to physician's offices because most physicians were forced by government mandates to take the shots and now may still be shedding, and the people in the waiting room may be shedding. So I didn't recognize any reason to go to a primary care nurse practitioner who possibly has never heard of Nattokinase, to monitor my use of Nattokinase. But now it seems like it would have been a great idea to monitor some of the labs to make sure that Nattokinase was not causing some serious abnormalities regarding clotting. I have no doubt it dissolves spike protein and has many other benefits, but there is also a serious downside. I'm glad I didn't hit my head when I fell, as that may have caused a massive brain bleed. But this hemarthrosis in my knee is at the moment quite a bad enough problem. (I do have the orthopedic surgeon and a gastroenterologist looking after me, but it is concerning that I have had additional bleeding even a week or more after I had stopped Nattokinase; I've never had a bleeding / clotting disorder, and it seems that this is probably a major factor in my experience, particularly in light of what Google Gemini has said.)
A bad thing about supplements is, supposedly the are safe enough to be taken without prescription - but I think not always - and there is no official FDA approved label to go to, to compare the adverse effects of the supplement with the adverse events of a placebo. There are no official warnings to read. Many supplements are safe enough for anyone to take without any monitoring, but I have not been taking any blood thinners other than Nattokinase - which I didn't know was a potent blood thinner that could knock out my Factor VIII etc. I'll probably never take it again, though if I would have realized, I would have gotten some lab monitoring, and taken a pause or decreased the dose if lab results were abnormal. The thing is, though, if I had gone to a nurse practitioner, and NPs are who seem to provide most of the primary care in my area, I feel sure they would not have had any idea of what to monitor - I find the NPs in my area have rather limited knowledge and skill, many are quite young and there is only so much that can be taught and learned in 18 months of medical school. I am actually a health professional, but my specialty is not cardiology, hematology or Covid, and I didn't know that Nattokinase could do this. It would be a service if the Wellness Company would educate to some extent about the beneficial effects as well as precautions appropriate to Nattokinase. Such as not taking it if one is taking a blood thinner, and I think, monitoring labs perhaps infrequently, just to make sure the dosage being used isn't getting labs dangerously out of range.
Martha72- thank you for this detailed response and I’m so glad you did not knock your head and bleed out. You lived to create this response to nattokinase consumption and I hope AI can access this text in future for people who want to know about nattokinase. I think AI Gemini and others do NOT have access to Substack texts.
I’m trying to find out how much nattokinase to take to break down the spike proteins after three vaccinations. Is it a one time course that is needed, or do we need nattokinase for life? Or do we need it for a three month stretch then take a break for a year? How does it work?
It is interesting that nattokinase reduces blood pressure as a blood thinner! Very useful information. But it sounds like one needs to follow through with blood tests every three months(?) to be sure not to over do it.
Thx
This is not my speciality, and I can't give general recommendations. I wish Dr. McCullough would say, "Ask your primary doctor to check D-dimer levels" or whatever they use to check for spike so you know if that is improving, AND I wish he would say "if you are taking nattokinase, talk to your primary care professional and ask about blood monitoring such as tests x, y, and z." I would not give personal medical recommendations online like this, but I can't really even give general recommendations - I'm sure not everyone has these effects because so many of the studies say "no side effects!" but - I didn't have the side effects until I fell, then I had all that bleeding into my knee - and there are people who might have had a lot of bruising after an accident who would not connect the dots to the nattokinase, both patients and providers - I never studied nattokinase in medical school, and I also have never managed patients on coumadin or nattokinase in my particular speciality, so I don't know. I would suppose if you check blood tests after a couple weeks or so, and again in 3 months - if it is staying the same and the dose is the same, I don't know, maybe quarterly for a year and if the labs are staying normal and there are no side effects, maybe just annually - but I don't know for sure which tests to do. Also, it is recommended that you stop nattokinase in advance of surgery - now, it is emergency surgery, your stuck with whatever it is, but for elective surgery that you are planning, I read a week or two for nattokinase, and both Google Gemini and I reasoned it out and thought two weeks ought to be sufficient, for me, I had some additional bruising show up on my foot for no reason at about the two week point, I can't guarantee that two weeks is adequate, but I think so - Anyway, if you have a good primary physician and you show them what I wrote or ask Gemini yourself, hopefully your doctor will know what labs to check. It is unfortunate that the only meds we are taught about in med school or PA school etc. are meds on which pharma can make money, and then there are other potentially useful meds that people take that health professionals are never taught about at all, and basically if it is something that pharma is not making money on, we are not taught about it. We're taught only about FDA-approved meds, and there are other things that people take - and the health professionals are uninformed and often have to say "I don't know" and then they are very uncomfortable about it because we don't know, but we're still likely to be held responsible if something goes wrong with your health. So - I suppose the best thing to do is to get with a telemed doctor from what used to be the FLCCC - they have a list of doctors who follow their Covid protocols, it's now the Independent Medical Alliance at https://imahealth.org/ and they have lists of providers so you can find someone in your state - IF your own primary doctor doesn't want you to take nattokinase or does not know how to monitor it, I would think (hope) that one of the IMA doctors would know. As for Gemini, the thing about AI, no, they would not have read substack, but they read pretty widely in their training and Gemini gives references for what it finds for me - but I try to verify because they give the warning that AI can make mistakes, and I have seen a few - and I correct it and show additional information so that the AI will know better another time. So - just now I thought - I should ask Gemini (who I find to be the most useful for me) about the labs. I will paste that in as a separate reply in case this is helpful. If you have a primary care doctor, you can discuss with your doctor, or you can find a potential doctor through the IMA as above or - it normally would involve an office visit or virtual office visit with a professional who can order the labs.
This is NOT "medical advice" but rather, just education / information and to get actual medical advice on this requires a visit with an MD, DO, PA or nurse practitioner. This, below, is a copy and paste from Google Gemini Pro 2.5 in answer to my question about blood tests that should be done to monitor someone if taking nattokinase. I pointed out that some health care practitioners may not be very familiar with nattokinase. Here's Gemini:
You're right to be concerned about monitoring someone taking nattokinase, even though it's an over-the-counter supplement. Nattokinase has fibrinolytic (clot-dissolving) and anticoagulant (blood-thinning) properties, which can increase the risk of bleeding, especially if combined with other medications that affect clotting. Healthcare providers who are not familiar with this supplement might not know what to monitor.
Here's information on labs that may be considered useful to monitor someone taking nattokinase to assess for bleeding/clotting disorders:
Key Labs to Consider for Monitoring Bleeding/Clotting Risk:
Prothrombin Time (PT) / International Normalized Ratio (INR):
What they measure: PT measures how long it takes for blood to clot, and INR standardizes this measurement, especially important for those on warfarin. While nattokinase doesn't directly act on the Vitamin K clotting cascade like warfarin, some studies have monitored INR in patients taking nattokinase, particularly if they are also on anticoagulants.
Why it's useful: A prolonged PT/elevated INR could indicate increased bleeding risk.
Activated Partial Thromboplastin Time (aPTT):
What it measures: aPTT measures the time it takes for blood to clot via the intrinsic and common pathways of coagulation.
Why it's useful: An increased aPTT could also suggest an increased bleeding tendency.
D-dimer:
What it measures: D-dimer is a protein fragment produced when a blood clot is broken down by fibrinolysis. Elevated D-dimer levels indicate that clot breakdown is occurring.
Why it's useful: Nattokinase is known to enhance fibrinolysis. An increase in D-dimer could indicate that the nattokinase is actively breaking down fibrin, which is its intended effect, but also underscores its potential impact on the clotting system.
Fibrinogen:
What it measures: Fibrinogen is a protein that is converted to fibrin, which forms the meshwork of a blood clot.
Why it's useful: Nattokinase directly degrades fibrin and may lower fibrinogen levels. Significantly reduced fibrinogen levels could contribute to an increased bleeding risk.
Platelet Count and Function Tests:
What they measure: Platelet count determines the number of platelets in the blood. Platelet function tests (e.g., platelet aggregation studies) assess how well platelets are working.
Why it's useful: While nattokinase's primary action is on fibrinolysis, it has also been reported to have anti-platelet effects. Monitoring platelet count and function could be important, especially if someone is also taking antiplatelet medications like aspirin.
Important Considerations for Healthcare Providers:
Baseline Labs: It's crucial to obtain baseline blood tests before someone starts taking nattokinase to establish their normal clotting profile.
Concomitant Medications: This is perhaps the most critical factor. Nattokinase can significantly increase the risk of bleeding when taken with other medications that thin the blood, including:
Anticoagulants: Warfarin (Coumadin), direct oral anticoagulants (DOACs) like apixaban (Eliquis), rivaroxaban (Xarelto), dabigatran (Pradaxa), edoxaban (Savaysa), and heparin.
Antiplatelet medications: Aspirin, clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta).
Other natural supplements with blood-thinning properties: Garlic, ginger, ginkgo biloba, fish oil (omega-3 fatty acids) in high doses, vitamin E.
Surgical Procedures: Nattokinase should be discontinued at least two weeks before any surgical procedure (including dental surgery) to minimize bleeding complications.
Bleeding History/Disorders: Individuals with a history of bleeding disorders (e.g., hemophilia), hemorrhagic stroke, or active bleeding should generally avoid nattokinase.
Clinical Symptoms: Beyond lab tests, it's vital to monitor for clinical signs of bleeding, such as:
Easy bruising
Nosebleeds
Bleeding gums
Prolonged bleeding from minor cuts
Unusual or heavy menstrual bleeding
Red or black stools (indicating gastrointestinal bleeding)
Dark urine
Severe headaches (could indicate intracranial bleeding)
Unexplained dizziness or weakness
Disclaimer: This information is for educational purposes and should not be considered medical advice. Anyone taking nattokinase, especially if they have underlying health conditions or are on other medications, should be closely monitored by a qualified healthcare professional who can determine the appropriate monitoring strategy based on their individual circumstances.
Sources: https://www.droracle.ai/articles/97383/does-4000-units-of-nattokinase-haveany-blood-thinning- https://pmc.ncbi.nlm.nih.gov/articles/PMC6043915/#:~:text=In%20addition%2C%20in%20a%20model,23 https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1380727/full https://pmc.ncbi.nlm.nih.gov/articles/PMC3879341/#:~:text=In%20the%20present%20study%2C%20we,platelet%20aggregation%20as%20action%20mechanisms. https://www.droracle.ai/articles/97383/does-4000-units-of-nattokinase-haveany-blood-thinning- https://www.myamyloidosisteam.com/resources/can-nattokinase-help-amyloidosis-learn-the-facts https://www.webmd.com/vitamins-and-supplements/nattokinase-uses-and-risks [End copy and paste from Gemini Pro 2.5] Note that when I asked Gemini these sources were provided, at the end of the post it says "Sources," you click on that, and then you see all the links and a thumbnail of each one at the margin, AND when I click there to go to the documents, the important parts are highlighted, and they are from medical journals and educational sources like Web MD. Again, I am not giving you advice on what you should do BUT I do think generally if anyone is thinking about Nattokinase, read about it first, AND then find a doctor who will help you with it and help you to stay safe. There is a lot to consider. I actually do not think it should be non-prescription, and it is not something to be taken without partnering with a health care professional. It is a serious medication with serious effects. Even the usual recommended dose can cause these effects. And some people should not take nattokinase at all.
Fabulous interview. I learn new things every time I listen to you do another interview.
Same here!
God Bless!!
dr mccullough ~ i suffered a terrible vaccine reaction in 2021 and your spike support and written material were both helpful in my recovery. as a result i was happy to be one of the first to reply to john leake's appeal to readers to give a review on amazon. and as much as i am grateful for your work, i must point out that i find it hard to believe you would approve of misrepresentation of products at twc. ultimate spike has on the label "4x more nattokinase" when it simply does not. it has exactly the same amount per capsule (100 mg), the same number of capsules per jar (120) and it recommends taking twice as much (4 caps) per dose as compared to regular spike (2 caps) which only equates to 2x as much per dose. it costs $22.50 more for a bottle that lasts half as long. that false advertisement makes me question other products with apparently excessive pricing: $124.00 for toothpaste, $499.99 for weightloss drops and $599.99 for a parasite cleanse!
i wrote to twc and received an automated reply that didn't deal with the issue, then wrote a note to john in response to his appeal for support for your book... crickets. so i am writing to you. i hope you care enough to look into it and at least press them to correct the false advertising. as for me, i'm shopping elsewhere from now on.
ps - i had to buy a subscription just to get you this message.
Jef how much nattokinase does one have to take to break down the spike proteins after the Covid vaccines? Is it a one time dose of 30 days or do we have to take nattokinase everyday for the rest of our lives? Is it true that bromelaine in pineapple breaks down the mRNA? Is one pineapple enough to breakdown the mRNA? Or is pineapple now needed every day for the rest of our lives? (Which of course is very hard to sustain). Are you”spike proteins the same as mRNA? I’m not getting answers even when I read the material but you seem to know from experience the hard way.
hey dana ~ hope you are doing ok. just so it's clear, i'm not a doctor, not that it would automatically qualify me as to knowing what i'm talking about! however, regarding how much nattokinase to use or for how long depends on your own symptoms and toxicity. being that nattokinase thins the blood, as martha made clear in her comment, be sure that you don't have a problem there. i didn't and had no problems when taking it. i would say that using the product you choose according to directions makes the most sense and to take it for two to four weeks and see how you feel. it could be you need more or not. it also might help in conjunction with other support mechanisms such as bromelaine (yes it does help with spike) or ivermectin or quercetin, etc. you could use spike support from twc or alternatively you could use zstack or zspike or both from zstacklife.com. there is no nattokinase in either of those products and they still serve the same purpose. i was in terrible shape with myelitis (spinal inflamation) and a long list of symptoms that occurred as well. i found dr. sayed haider at mygotodoc who prescribed ivermectin, fluvoxamine, prenisone, nac, and vitamins, and i got nattokinase on my own and after two months at the recommended dosage i was feeling significantly better. it took me a couple of months to come around from excruciating disabling pain to tolerable limits without pain killers.
regarding mrna and spike, it's my understand thus far that toxic lipid nano particles deliver synthetic mrna (not like our own) to the cells and express the toxic spike protein and cause our immune system to respond by attacking our own tissues. apparently there is no virus involved, just a synthetic bioweapon meant to maim and kill. and being that this nanotech is now in our air, water, soil and food, including all other species, we will be combatting it into the forseeable future. however, i personally don't like the notion of supplementing my system constantly. i take my supplements for a two to three weeks and if i'm feeling well i stop for a time. i don't like to idea of juicing up my system constantly, i like to find my own stasis, to hold my own and not rely on supplementation, but instead just try to eat well and get regular exercise, which used to be skiing, biking, hiking, etc, but now is just walk the dog, but i'm still working on it.
there's lots of great people to read: sasha latypova, midwestern doctor, dr. anita baxas, christine massey, dr. william makis, doc malik, dr sam bailey, dr joseph mercola, dr sayed haider, dr tenpenny, the forgotten side of medicine, superspreader, etc., all on substack. endless info with them. i have also been following dr ardis online, using his edta for detox, and just got zeolite capsules through dr andrew kaufman at mendicamentum authentica for detox as well. i like to switch things up and not use one thing too much. presently i'm doing a detox following protocol 1000 using chlorine dioxide. it's weird, i smell chlorine all day long, but i want to see what happens.
i hope some of this helps and hope you are well, or on your way to feeling well. it's hard to feel positive in a world where the powers that be are making efforts to harm us, but i believe there are also many people making an honest effort to make the world a better place and help each other to heal, despite our limitations and personal biases. peace...
\💉 ª X https://turbocancer.org
Hi there just looking for some advice… when i got the booster about a year ago two days later my conjecture is that i started having a cytokine storm which in emergency was going out of my brain can’t explain the feeling…kind like feeling manic, losing my mind,about to faint,delirious and nearly died with doctors sadistically smiling almost hoping i would die but i didn’t somehow…a week later i looked at discharge papers and had a CRP of 92 with anything over 50 considered an emergency either sepsis or systemic inflammation..they gave me no prednisone so a new MRI showed four large glioses and glial scarring which must have been from the vaccine and malicious failure to treat …anyway over next few months realised i had nearly died over ten times by a very serious form of epilepsy called status epilepticus and myoclonic seizures i was forced to diagnose through obvious systems as doctors or many of them know jack shit nor do they care…my question is that i feel pretty fine but since the spike proteins circulate throughout the body and brain for life would a spike detox still help
another great book on vaccines: Turtles all the way down: Vaccine Science & Myth
Bought "Vaccines: Mythology, Ideology and Reality"! Looking forward to reading it!
Too bad, but I'm disappointed in the interviewer who did not embark at all on the "Mythology and Ideology" subjects--the crucial sociological aspects many of us want to know about.
Exactly what are the driving forces behind the public's irrational beliefs about vaccines? Fortunately John, (towards the 30 minute mark) had a chance to compare the seemingly startling powers of vaccines to the "act of falling in love"--to which I assume means feeling safe and cared for, etc. Now, we are making sense if we want to somehow overcome the heavy lead fortress of unconscious beliefs that are imprisoning the mind.
The interview was mechanistic in that it just covered physiology and legislature--things most of us know about (Flexner Report, GAVI, DARPA, SV40, DNA plasmids..), which is not bad in itself, but far from being educational about mass hysteria.
The Polio Vaccine was not a effective of safe. Read A Midwestern Doctor substack on Polio. My much older than me cousin was incapacitated by the polio vaccine having to use crutches thru HS. He still cannot run.
The placebo effect and the power of suggestion.
If I tell you over and over again that you will get scarlet fever, at some point you will probably get scarlet fever. If I tell you over and over again that you will get covid, at some point you probably will get covid. If I then give you a 'shot' and tell you that this is going to help, you're going to believe it enough that it will. Though in some cases it will not.