I joined Del Bigtree in studio on The HighWire to discuss what the data now make unavoidable: the CDC’s 81-dose hyper-vaccination schedule is driving the modern epidemics of chronic disease and autism.
This was not a philosophical debate or a clash of opinions. We walked through irrefutable, peer-reviewed evidence showing that whenever vaccinated and unvaccinated children are compared directly, the unvaccinated group is far healthier—every single time.
Reanalyzing the Largest Vaccinated vs. Unvaccinated Birth-Cohort Study Ever Conducted
At the center of our discussion was our peer-reviewed reanalysis of the Henry Ford Health System vaccinated vs. unvaccinated birth-cohort study (Lamerato et al.)—the largest and most rigorous comparison of its kind ever conducted.
The original authors relied heavily on Cox proportional hazards models, a time-adjusted approach that can soften absolute disease burden. Even so, nearly all chronic disease outcomes were higher in vaccinated children.
Our reanalysis used direct proportional comparisons, stripping away the smoothing and revealing the full magnitude of the signal.
All 22 chronic disease categories favored the unvaccinated cohort when proportional disease burden was examined
Cancer incidence was 54% higher in vaccinated children (0.0102 vs. 0.0066)
When autism-associated conditions were grouped appropriately—including autism, ADHD, developmental delay, learning disability, speech disorder, neurologic impairment, seizures, and related diagnoses—the vaccinated cohort showed a 549% higher odds of autism-spectrum–associated clinical outcomes
The findings are internally consistent, biologically coherent, and concordant with every prior vaccinated vs. unvaccinated study, all of which show drastically poorer health outcomes among vaccinated children
The 12 Vaccinated vs. Unvaccinated Studies Regulators Ignore
In the McCullough Foundation Autism Report, we compiled all 12 vaccinated vs. unvaccinated pediatric studies currently available. These studies span different populations, countries, study designs, and data sources.
Every single one reports the same overall pattern. Across all 12 studies, unvaccinated children consistently exhibit substantially lower rates of chronic disease, including:
Autism and other neurodevelopmental disorders
ADHD, tics, learning and speech disorders
Asthma, allergies, eczema, and autoimmune conditions
Chronic ear infections, skin disorders, and gastrointestinal illness
This level of consistency across independent datasets is precisely what epidemiology looks for when assessing causality. It also explains why no federal agency has ever conducted—or endorsed—a fully vaccinated vs. fully unvaccinated safety study.
Flu Shot Failure
We also addressed the persistent failure of seasonal influenza vaccination.
A large Cleveland Clinic cohort study of 53,402 employees followed participants during the 2024–2025 respiratory viral season and found:
82.1% of employees were vaccinated against influenza
Vaccinated individuals had a 27% higher adjusted risk of influenza compared with the unvaccinated state (HR 1.27; 95% CI 1.07–1.51; p = 0.007)
This corresponded to a negative vaccine effectiveness of −26.9% (95% CI −55.0 to −6.6%), meaning vaccination was associated with increased—not reduced—risk of influenza
When vaccination exposure increases, chronic disease, neurodevelopmental disorders, and inflammatory illness increase with it. When children are unvaccinated, they are measurably healthier across virtually every outcome that matters.
The science needed to confront the chronic disease and autism epidemics already exists. What remains is the willingness to acknowledge it.
Epidemiologist and Foundation Administrator, McCullough Foundation
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