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Ivermectin Plus Mebendazole: Mechanisms, Observational Outcomes, and the Case for Randomized Trials

Will the MAHA Coalition push HHS for large, prospective, parallel-group, double-blind, placebo-controlled, clinical trials?

By Peter A. McCullough, MD, MPH

If you or a loved one are battling cancer, should you consider adding the combination of ivermectin-mebendazole to your regimen? Dr Gina Loudon weighed in on this question with Dr McCullough on American Sunrise, Real America’s Voice.

🎙️ Ivermectin-Mebendazole Cancer Breakthrough

Dr. Peter McCullough joined Dr. Gina Loudon on Real America’s Voice to discuss a landmark study published in the peer-reviewed, highly respected, Anti-Cancer Research Journal — the first ever examining ivermectin and mebendazole in combination for cancer treatment.


🔬 The Study

The Wellness Company conducted a human observational study tracking cancer patients using off-label ivermectin-mebendazole (typically one tablet daily, some twice daily). Results were striking:

  • 84% of patients experienced clinical benefit — either cancer stabilization or regression

  • Over 90% stayed on the medication

  • ~25% reported side effects, largely GI-related and manageable

McCullough emphasized this was “real world patient reported outcome” research — observing actual use and outcomes rather than controlled trial conditions.

Hulscher N, Victory K, Thorp JA, Pinsky D, Diaz-Villalobos A, Gillooly P, Coulson F, Annazone M, Radesi C, Brooks J, McCULLOUGH PA, Risch H. Real-world Clinical Outcomes of Ivermectin and Mebendazole in Cancer Patients: Results from a Prospective Observational Cohort. Anticancer Res. 2026 Jun;46(6):3243-3255. doi: 10.21873/anticanres.18194. PMID: 42203321.

🧬 Mechanism of Action

The drugs work through three distinct pathways:

  1. Reduced cancer cell proliferation

  2. Cutting off blood supply to tumors

  3. Accelerated apoptosis — the body’s natural cleanup and clearance of cancer cells


💰 The Cancer Center Problem

McCullough and Loudon pointed to the “book and bill” system that incentivizes cancer centers to push expensive chemotherapy rather than investigate cheap generics. While cancer treatment generates billions annually, inexpensive options like ivermectin-mebendazole get ignored because there’s no profit motive.


🏛️ What’s Next

McCullough revealed results have been sent to RFK Jr. at HHS and Dr. Jay Bhattacharya, urging government-sponsored double-blind randomized placebo-controlled trials through the National Cancer Institute. The MAHA coalition made a public push for psychedelics in PTSD and treatment resistant depression; will they do the same for IVM-Meb in cancer?

“What are they waiting for?” — McCullough

The Wellness Company offers 100% American-made ivermectin and mebendazole direct to consumers, positioning itself as an alternative to “Big Pharma’s greed and poisons.” McCullough noted many oncologists are now accepting of patients using these adjunctively with traditional treatment.

FOCAL POINTS (Courageous Discourse) is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Peter A. McCullough, MD, MPH

Chief Scientific Officer, The Wellness Company

https://www.twc.health/pages/focal-points

Hulscher N, Victory K, Thorp JA, Pinsky D, Diaz-Villalobos A, Gillooly P, Coulson F, Annazone M, Radesi C, Brooks J, McCULLOUGH PA, Risch H. Real-world Clinical Outcomes of Ivermectin and Mebendazole in Cancer Patients: Results from a Prospective Observational Cohort. Anticancer Res. 2026 Jun;46(6):3243-3255. doi: 10.21873/anticanres.18194. PMID: 42203321.

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